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Prospective study of cytotoxic and genotoxic effects of Combretastatin
(European Environmental Mutagenesis and Genomics Society (EEMGS), 2023)
Combretastatins are a class of natural phenols found in the bark of Combretum
caffrum, commonly known as South African Bush Willow. Despite having a similar
name, combretastatins are unrelated to statins, a family of ...
Examination of the effects of X-ray phase contrast imaging dose on DNA in mesenchymal stem cells by comet assay
(Savez hemijskih inženjera, Beograd, 2024)
INTRODUCTION: Imaging techniques based on X-ray phase-contrast (XPC) have shown tremendous promise for applications involving biomaterials and soft tissue formation [1,2].XPC imaging can be applied at higher ...
Unexpected effect of dry olive leaf extract (DOLE) before and after CaNa2EDTA chelation therapy in comet assay in lead intoxicated workers
(International Congress on Occupational & Environmental Toxicology - ICOETox 2016, 2016)
The CaNa2EDTA chelation is a standard therapy for lead (Pb) intoxication in occupationally exposed workers. Application of antioxidant nutrients through exogenous supplementation is often practiced with the chelation ...
Evaluation of adrenaline-induced DNA damage in vitro by comet assay
(National Health Institute Dr. Ricardo JorgeInstitute of Public Health of the University of Porto (ISPUP), 2018)
Experimental evidence has shown the ability of adrenaline to cause changes in DNA, affirming that damaging effects occurs during the oxidation of the hormone. Longterm research in this area would surmise that the mechanisms ...
Surface-modified TiO2 nanoparticles with ascorbic acid: antioxidant properties and efficiency against DNA damage
(International Congress on Occupational & Environmental Toxicology - ICOETox 2016, 2016)
Ascorbic acid (AA) is a standard antioxidant and its radical scavenging properties also appear to be responsible for its antigenotoxic properties. Nanoparticle-mediated delivery of antioxidant compounds is intended to ...
Dry olive leaf extract supplementation reduces DNA damage in chronic rheumatoid arthritis patients
(Center for Molecular Medicine Cologne, University of Cologne, 2014)
Increased oxidative stress caused by chronic inflammation is one of the underlying mechanisms in etiology of rheumatoid arthritis (RA). Reactive oxygen species produced during inflammatory response target cells DNA leading ...
Evaluation of repair kinetics of oxidative damaged DNA in peripheral blood leukocytes treated with chaga mushroom (Inonotus obliquus) extract in vitro
(International Comet Assay Working Group (ICAWG), 2019)
Inonotus obliquus, edible medicinal mushroom found in northern hemisphere, is widely used for the prevention and treatment of cancer, diabetes, colitis and asthma. Its bioactives, triterpens, polysaccharides and polyphenols ...
Assessment of DNA damage in blood, liver and kidney cells in a hypertensive rat model using comet assay
(Institute for Genetic Engineering and Biotechnology, University of Sarajevo, 2019)
Hypertension is one of the primary risk factors for heart disease and stroke, the leading causes of death worldwide. Numerous factors have been implicated in the pathophysiology of hypertension: endothelial dysfunction, ...
Antigenotoxic effect of quercetin on thyroxine-induced DNA damage in human whole blood cells in vitro
(Institute for Genetic Engineering and Biotechnology, University of Sarajevo, 2019)
The binding of thyroid hormones to specific nuclear receptors in target cells induces synthesis of enzymes associated with redox processes, leading to the formation of reactive oxygen species (ROS), which can cause damage ...