Clinically important interactions of antibiotics and antifungal drugs with other drugs

Abstract

Antibiotics (AB) and antifungals are large, heterogeneous, and commonly prescribed groups of drugs. Even thou, their use in therapy are considered to be safe, during concomitant use with other drugs the result can be clinically important interaction. Certain classes of AB or antifungal drugs are known to interact with many other drugs, but the interaction potential of them is not uniform among members of the class. Therefore, choosing the appropriate drug allows the possibility to avoid potentially dangerous drug-drug interactions.

Antibiotici (AB) i antimikotici predstavljaju velike, heterogene i često propisivane grupe lekova. Iako se smatraju za relativno bezbedne lekove, pri istovremenoj primeni sa drugim lekovima mogu da stupe u klinički značajne interakcije. Određene grupe AB i antimikotika su poznate da stupaju u interakcije, ali potencijal za stupanje u interakcije unutar istih klasa lekova je različit, što pruža mogućnost da se odgovarajućim odabirom AB odnosno antimikotika izbegnu potencijalno štetne lek-lek interakcije.