FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Microemulsion systems: Characteristics and application in drug delivery

Mikroemulzioni sistemi - osobine i primena kao nosača lekovitih supstanci

Thumbnail
2007
1014.pdf (439.9Kb)
Authors
Đekić, Ljiljana
Primorac, Marija
Article (Published version)
Metadata
Show full item record
Abstract
During the last three decades there were intensive investigations on potential application of microemulsion colloidal vehicles in drug delivery. Researchers had put the greatest effort in investigation of oral, dermal/transdermal, ocular and parenteral delivery of drugs from microemulsions. Numerous applications of these systems lie in their unique properties: termodinamical stability, heterogenous microstructure with dynamic character, ultralow surface tension, large interface area and significant capacity for solubilisation of hydrophilic and lipophilic drugs. In general, the observations obtained within numerous studies, pointed out the efficacy of O/W, W/O and bicontinuous microemulsions, as well as Self-Microemulsifying Drug Delivery Systems (SMEDDS), to improve bioavailability of drugs with low solubility and/or low permeability. Therefore, microemulsions are current reaction media for synthesis of nanoparticulate carriers of drugs (Solid Lipid Nanoparticles (SLN), polymeric nano...particles) as well as for nanoingenireeng of poorly soluble drugs.

Tokom poslednjih trideset godina intenzivno se istražuju mogućnosti za primenu koloidnih vehikuluma tipa mikroemulzija za isporuku lekovitih supstanci na odgovarajuće mesto u organizmu. Najveći napori uloženi su na polju istraživanja peroralne, dermalne/transdermalne, okularne i parenteralne isporuke lekova iz mikroemulzija. Raznovrsna primena ovih sistema zasniva se na njihovim jedinstvenim karakteristikama: termodinamička stabilnost, dinamički karakter i heterogenost mikrostrukture, izuzetno (ultra) nizak međupovršinski napon, velika međupovršina i značajan kapacitet za solubilizaciju/rastvaranje hidrosolubilnih i liposolubilnih lekovitih supstanci. Generalizovana zapažanja u sprovedenim istraživanjima ukazuju na efikasnost mikroemulzija tipa ulje u vodi (U/V), voda u ulju (V/U) i bikontinuiranih mikroemulzija, kao i samo-mikroemulgujućih sistema za isporuku lekova (eng. Self- Microemulsifying Drug Delivery Systems - SMEDDS), u smislu poboljšavanja biološke raspoloživosti slabo rastv...orljivih i/ili slabo permeabilnih lekova. Osim toga, mikroemulzije se upotrebljavaju kao reakcioni medijumi za dobijanje nanočestičnih nosača za lekovite supstance tipa čvrstih lipidnih nanočestica (eng. Solid Lipid Nanoparticles - SLN) i polimernih nanočestica, kao i za nanoinžinjering slabo rastvorljivih lekovitih supstanci.

Keywords:
microemulsion systems for oral / dermal/transdermal / ocular or parenteral drug delivery / SMEDDS / Solid Lipid Nanoparticles / nanoingenireeng of drugs / polymeric nanoparticles / mikroemulzioni sistemi za peroralnu / dermalnu/transdermalnu / oftalmološku ili parenteralnu isporuka lekova / SMEDDS / čvrste lipidne nanočestice / nanoinžinjering lekova / polimerne nanočestice
Source:
Arhiv za farmaciju, 2007, 57, 6, 355-374
Publisher:
  • Savez farmaceutskih udruženja Srbije, Beograd

ISSN: 0004-1963

[ Google Scholar ]
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1016
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB