Show simple item record

dc.creatorŽarković, Miloš
dc.creatorIgnjatović, Svetlana
dc.creatorDajak, Marijana
dc.creatorĆirić, Jasmina
dc.creatorBeleslin, Biljana
dc.creatorSavić, Slavica
dc.creatorStojković, Mirjana
dc.creatorBulat, Petar
dc.creatorTrbojević, Bozo
dc.date.accessioned2019-09-02T11:12:15Z
dc.date.available2019-09-02T11:12:15Z
dc.date.issued2008
dc.identifier.issn0804-4643
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1026
dc.description.abstractObjective: Interleukin 6(IL6) has the ability to influence each level of the hypothalamo-pituitary-adrenocortical (HPA) axis. The aim of the study was to test whether IL6 concentration correlates with the adrenal cortex response to ACTH in healthy humans. We postulated that higher basal IL6 concentration would be associated with the higher cortisol response to the stimulation. Design and methods: Basal IL6 concentration was measured and a low dose (1 mu g) ACTH test was performed to assess cortisol response. apparently healthy Subjects (11 male. 16 female. mean age 31.1 years. age range 22-47 years) were included in the study. Results: Data are presented as mean +/- S.E.M. Basal IL6 level was 0.84 +/- 0.10 pg/ml, Basal cortisol was 351.9 +/- 18.3. nmol/l. Maximal cortisol during synacthen test was 653.0 +/- 20.6 nmol/l. Maximal cortisol increment was 301.1 +/- 20.0 nmol/l. IL6 concentration was not correlated with basal or maximal cortisol concentration. but correlated significantly with cortisol increment (r=0.63. 95%. confidence interval) 0.42-0.83). Conclusions: In our study. We found that higher basal IL6 concentration is associated with the higher cortisol response to ACTH stimulation. Based on previous research and our data, IL6, even in low concentrations and under physiologic conditions, modulates adrenal cortex responsivity to ACTH. Therefore. it seems that immune modulation of HPA axis is also present under physiologic and not only pathologic conditions.en
dc.publisherBioscientifica Ltd, Bristol
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145031/RS//
dc.rightsopenAccess
dc.sourceEuropean Journal of Endocrinology
dc.titleCortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humansen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБулат, Петар; Трбојевић, Бозо; Белеслин, Биљана; Ћирић, Јасмина; Жарковић, Милош; Дајак, Маријана; Стојковић, Мирјана; Игњатовић, Светлана; Савић, Славица;
dc.citation.volume159
dc.citation.issue5
dc.citation.spage649
dc.citation.epage652
dc.citation.other159(5): 649-652
dc.citation.rankM22
dc.identifier.wos000260965600021
dc.identifier.doi10.1530/EJE-08-0544
dc.identifier.pmid18753312
dc.identifier.scopus2-s2.0-56749092171
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/23/1024.pdf
dc.identifier.rcubconv_2089
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record