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Role of complexes formation between drugs and penetration enhancers in transdermal delivery

Authorized Users Only
2008
Authors
Drakulić, Branko
Juranić, Ivan O.
Erić, Slavica
Zloh, Mire
Article (Published version)
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Abstract
The use of chemical penetration enhancers (CPE) is growing due to their ability to improve drug delivery through the skin. A possible mechanism of penetration enhancement could involve the complex formation between drug and components in the pharmaceutical formulation, thus altering the physicochemical properties of the active substance. Here, modelling studies indicate that hydrocarbon and oxygen-containing terpenes (penetration enhancers) could form complexes with drugs. Satisfactory correlations have been obtained between the predicted molecular properties of enhancers and their enhancement effects. Crown Copyright
Keywords:
Conformational search / Small molecule-small molecule / interactions / Transdermal delivery / Penetration enhancers
Source:
International Journal of Pharmaceutics, 2008, 363, 1-2, 40-49
Publisher:
  • Elsevier Science BV, Amsterdam
Projects:
  • Synthesis, characterization and activity of organic and coordination composition and their application in (bio) nanotechnology (RS-142010)

DOI: 10.1016/j.ijpharm.2008.06.032

ISSN: 0378-5173

PubMed: 18675333

WoS: 000260478700003

Scopus: 2-s2.0-51749091289
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1029
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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