FarFaR - Farmaceutski fakultet, repozitorijum
Univerzitet u Beogradu, Farmaceutski fakultet
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Role of complexes formation between drugs and penetration enhancers in transdermal delivery

Samo za registrovane korisnike
2008
Autori
Drakulić, Branko
Juranić, Ivan O.
Erić, Slavica
Zloh, Mire
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentu
Apstrakt
The use of chemical penetration enhancers (CPE) is growing due to their ability to improve drug delivery through the skin. A possible mechanism of penetration enhancement could involve the complex formation between drug and components in the pharmaceutical formulation, thus altering the physicochemical properties of the active substance. Here, modelling studies indicate that hydrocarbon and oxygen-containing terpenes (penetration enhancers) could form complexes with drugs. Satisfactory correlations have been obtained between the predicted molecular properties of enhancers and their enhancement effects. Crown Copyright
Ključne reči:
Conformational search / Small molecule-small molecule / interactions / Transdermal delivery / Penetration enhancers
Izvor:
International Journal of Pharmaceutics, 2008, 363, 1-2, 40-49
Izdavač:
  • Elsevier Science BV, Amsterdam
Projekti:
  • Sinteza, karakterizacija i aktivnost organskih i koordinacionih jedinjenja i njihova primena u (bio)nanotehnologiji (RS-142010)

DOI: 10.1016/j.ijpharm.2008.06.032

ISSN: 0378-5173

PubMed: 18675333

WoS: 000260478700003

Scopus: 2-s2.0-51749091289
[ Google Scholar ]
31
27
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1029
Kolekcije
  • Radovi istraživača / Researchers’ publications
Institucija
Pharmacy
TY  - JOUR
AU  - Drakulić, Branko
AU  - Juranić, Ivan O.
AU  - Erić, Slavica
AU  - Zloh, Mire
PY  - 2008
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1029
AB  - The use of chemical penetration enhancers (CPE) is growing due to their ability to improve drug delivery through the skin. A possible mechanism of penetration enhancement could involve the complex formation between drug and components in the pharmaceutical formulation, thus altering the physicochemical properties of the active substance. Here, modelling studies indicate that hydrocarbon and oxygen-containing terpenes (penetration enhancers) could form complexes with drugs. Satisfactory correlations have been obtained between the predicted molecular properties of enhancers and their enhancement effects. Crown Copyright
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Role of complexes formation between drugs and penetration enhancers in transdermal delivery
VL  - 363
IS  - 1-2
SP  - 40
EP  - 49
DO  - 10.1016/j.ijpharm.2008.06.032
ER  - 
@article{
author = "Drakulić, Branko and Juranić, Ivan O. and Erić, Slavica and Zloh, Mire",
year = "2008",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/1029",
abstract = "The use of chemical penetration enhancers (CPE) is growing due to their ability to improve drug delivery through the skin. A possible mechanism of penetration enhancement could involve the complex formation between drug and components in the pharmaceutical formulation, thus altering the physicochemical properties of the active substance. Here, modelling studies indicate that hydrocarbon and oxygen-containing terpenes (penetration enhancers) could form complexes with drugs. Satisfactory correlations have been obtained between the predicted molecular properties of enhancers and their enhancement effects. Crown Copyright",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Role of complexes formation between drugs and penetration enhancers in transdermal delivery",
volume = "363",
number = "1-2",
pages = "40-49",
doi = "10.1016/j.ijpharm.2008.06.032"
}
Drakulić B, Juranić IO, Erić S, Zloh M. Role of complexes formation between drugs and penetration enhancers in transdermal delivery. International Journal of Pharmaceutics. 2008;363(1-2):40-49
Drakulić, B., Juranić, I. O., Erić, S.,& Zloh, M. (2008). Role of complexes formation between drugs and penetration enhancers in transdermal delivery.
International Journal of PharmaceuticsElsevier Science BV, Amsterdam., 363(1-2), 40-49.
https://doi.org/10.1016/j.ijpharm.2008.06.032
Drakulić Branko, Juranić Ivan O., Erić Slavica, Zloh Mire, "Role of complexes formation between drugs and penetration enhancers in transdermal delivery" 363, no. 1-2 (2008):40-49,
https://doi.org/10.1016/j.ijpharm.2008.06.032 .

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