Natural Surfactant-Based Emulsion Systems: The Influence of Common Pharmaceutical Excipients on Colloidal Structure and Physical Stability
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2008
Authors
Savić, Snežana
Tamburić, Slobodanka
Kovacević, Anđelka
Daniels, Rolf
Mueller-Goymann, Christel
Article (Published version)

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There is a growing need for research into new skin- and environment-friendly surfactants. The aim of the study was to find out whether a combination of an alkylpolyglucoside natural surfactant with established pharmaceutical excipients could provide a solid pharmaceutical base with satisfied physical stability. The study was carried out in two phases: the first one focused on the colloidal structure of vehicles formulated with oils of different polarity and/or different costabilizer (lipophilic versus hydrophilic) and the second one evaluated vehicles' physical stability. A number of techniques were used (polarization, light, and transmission electron microscopy, pH, conductivity and thermogravimetric measurements, rheological analysis and cyclic temperature stress test). Natural surfactant's interaction with used excipients resulted in the formation of semisolid emulsion systems of different rheological profiles, stabilized predominantly by synergistic effects of lamellar liquid-cryst...alline (L alpha) and complex lamellar gel (L beta) phases. The type of used oil and costabilizer significantly influenced the colloidal structure of the vehicles, particularly in terms of water distribution mode and initial rheological performance as well as their physical stability. It was recommended that medium polar oils of ester type and lipophilic costabilizers, particularly long chain fatty alcohols, should be used in the formulation of stable alkylpolyglucoside-based topical vehicles.
Keywords:
Liquid crystals / natural surfactant / pharmaceutical excipients / physical stability / topical vehicleSource:
Journal of Dispersion Science and Technology, 2008, 29, 9, 1276-1287Publisher:
- Taylor & Francis Inc, Philadelphia
DOI: 10.1080/01932690701857558
ISSN: 0193-2691
WoS: 000260212600014
Scopus: 2-s2.0-55149094121
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PharmacyTY - JOUR AU - Savić, Snežana AU - Tamburić, Slobodanka AU - Kovacević, Anđelka AU - Daniels, Rolf AU - Mueller-Goymann, Christel PY - 2008 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1034 AB - There is a growing need for research into new skin- and environment-friendly surfactants. The aim of the study was to find out whether a combination of an alkylpolyglucoside natural surfactant with established pharmaceutical excipients could provide a solid pharmaceutical base with satisfied physical stability. The study was carried out in two phases: the first one focused on the colloidal structure of vehicles formulated with oils of different polarity and/or different costabilizer (lipophilic versus hydrophilic) and the second one evaluated vehicles' physical stability. A number of techniques were used (polarization, light, and transmission electron microscopy, pH, conductivity and thermogravimetric measurements, rheological analysis and cyclic temperature stress test). Natural surfactant's interaction with used excipients resulted in the formation of semisolid emulsion systems of different rheological profiles, stabilized predominantly by synergistic effects of lamellar liquid-crystalline (L alpha) and complex lamellar gel (L beta) phases. The type of used oil and costabilizer significantly influenced the colloidal structure of the vehicles, particularly in terms of water distribution mode and initial rheological performance as well as their physical stability. It was recommended that medium polar oils of ester type and lipophilic costabilizers, particularly long chain fatty alcohols, should be used in the formulation of stable alkylpolyglucoside-based topical vehicles. PB - Taylor & Francis Inc, Philadelphia T2 - Journal of Dispersion Science and Technology T1 - Natural Surfactant-Based Emulsion Systems: The Influence of Common Pharmaceutical Excipients on Colloidal Structure and Physical Stability VL - 29 IS - 9 SP - 1276 EP - 1287 DO - 10.1080/01932690701857558 ER -
@article{ author = "Savić, Snežana and Tamburić, Slobodanka and Kovacević, Anđelka and Daniels, Rolf and Mueller-Goymann, Christel", year = "2008", abstract = "There is a growing need for research into new skin- and environment-friendly surfactants. The aim of the study was to find out whether a combination of an alkylpolyglucoside natural surfactant with established pharmaceutical excipients could provide a solid pharmaceutical base with satisfied physical stability. The study was carried out in two phases: the first one focused on the colloidal structure of vehicles formulated with oils of different polarity and/or different costabilizer (lipophilic versus hydrophilic) and the second one evaluated vehicles' physical stability. A number of techniques were used (polarization, light, and transmission electron microscopy, pH, conductivity and thermogravimetric measurements, rheological analysis and cyclic temperature stress test). Natural surfactant's interaction with used excipients resulted in the formation of semisolid emulsion systems of different rheological profiles, stabilized predominantly by synergistic effects of lamellar liquid-crystalline (L alpha) and complex lamellar gel (L beta) phases. The type of used oil and costabilizer significantly influenced the colloidal structure of the vehicles, particularly in terms of water distribution mode and initial rheological performance as well as their physical stability. It was recommended that medium polar oils of ester type and lipophilic costabilizers, particularly long chain fatty alcohols, should be used in the formulation of stable alkylpolyglucoside-based topical vehicles.", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Journal of Dispersion Science and Technology", title = "Natural Surfactant-Based Emulsion Systems: The Influence of Common Pharmaceutical Excipients on Colloidal Structure and Physical Stability", volume = "29", number = "9", pages = "1276-1287", doi = "10.1080/01932690701857558" }
Savić, S., Tamburić, S., Kovacević, A., Daniels, R.,& Mueller-Goymann, C.. (2008). Natural Surfactant-Based Emulsion Systems: The Influence of Common Pharmaceutical Excipients on Colloidal Structure and Physical Stability. in Journal of Dispersion Science and Technology Taylor & Francis Inc, Philadelphia., 29(9), 1276-1287. https://doi.org/10.1080/01932690701857558
Savić S, Tamburić S, Kovacević A, Daniels R, Mueller-Goymann C. Natural Surfactant-Based Emulsion Systems: The Influence of Common Pharmaceutical Excipients on Colloidal Structure and Physical Stability. in Journal of Dispersion Science and Technology. 2008;29(9):1276-1287. doi:10.1080/01932690701857558 .
Savić, Snežana, Tamburić, Slobodanka, Kovacević, Anđelka, Daniels, Rolf, Mueller-Goymann, Christel, "Natural Surfactant-Based Emulsion Systems: The Influence of Common Pharmaceutical Excipients on Colloidal Structure and Physical Stability" in Journal of Dispersion Science and Technology, 29, no. 9 (2008):1276-1287, https://doi.org/10.1080/01932690701857558 . .