The Antiinflammatory, Gastroprotective and Antioxidant Activities of Hieracium gymnocephalum Extract
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2008
Authors
Petrović, Silvana
Dobrić, Silva

Mimica-Dukić, Neda

Simin, Nataša

Kukić, Jelena

Niketić, Marjan

Article (Published version)

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The present study investigated the antiinflammatory, gastroprotective and antioxidant activities of a CH(2)Cl(2) extract of western Balkan endemic Hieracium gymnocephalum Griseb. ex Pant. (Compositae). The carrageenan-induced rat paw oedema test was used as an experimental model for screening the antiinflammatory activity. The extract was administrated p.o. in doses of 25, 50, 100 and 200 mg/kg to rats and its effects compared with indomethacin, used p.o. as a reference drug. The results showed that the investigated extract reduced the oedema in a concentration-dependent manner. The obtained antiinflammatory effect was 5.9%, 11.7%, 31.2% and 44.1% at doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 100 mg/kg. Indomethacin had a strong antiinflammatory effect of 73.4% at a dose of 8 mg/kg, but caused large gastric lesions. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the and inflamm...atory effect was slightly enhanced, but the gastric lesions were significantly reduced. The antioxidant activity of the H. gymnocephalum extract, investigated using DPPH radical assay, OH-radical assay and TBA-test, was not substantial. Copyright
Keywords:
Hieracium gymnocephalum / anti-inflammatory activity / gastroprotective activity / antioxidant activitySource:
Phytotherapy Research, 2008, 22, 11, 1548-1551Publisher:
- John Wiley & Sons Ltd, Chichester
Funding / projects:
- Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija (RS-143012)
DOI: 10.1002/ptr.2485
ISSN: 0951-418X
PubMed: 18814212
WoS: 000261124900024
Scopus: 2-s2.0-57349167447
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PharmacyTY - JOUR AU - Petrović, Silvana AU - Dobrić, Silva AU - Mimica-Dukić, Neda AU - Simin, Nataša AU - Kukić, Jelena AU - Niketić, Marjan PY - 2008 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1037 AB - The present study investigated the antiinflammatory, gastroprotective and antioxidant activities of a CH(2)Cl(2) extract of western Balkan endemic Hieracium gymnocephalum Griseb. ex Pant. (Compositae). The carrageenan-induced rat paw oedema test was used as an experimental model for screening the antiinflammatory activity. The extract was administrated p.o. in doses of 25, 50, 100 and 200 mg/kg to rats and its effects compared with indomethacin, used p.o. as a reference drug. The results showed that the investigated extract reduced the oedema in a concentration-dependent manner. The obtained antiinflammatory effect was 5.9%, 11.7%, 31.2% and 44.1% at doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 100 mg/kg. Indomethacin had a strong antiinflammatory effect of 73.4% at a dose of 8 mg/kg, but caused large gastric lesions. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the and inflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The antioxidant activity of the H. gymnocephalum extract, investigated using DPPH radical assay, OH-radical assay and TBA-test, was not substantial. Copyright PB - John Wiley & Sons Ltd, Chichester T2 - Phytotherapy Research T1 - The Antiinflammatory, Gastroprotective and Antioxidant Activities of Hieracium gymnocephalum Extract VL - 22 IS - 11 SP - 1548 EP - 1551 DO - 10.1002/ptr.2485 ER -
@article{ author = "Petrović, Silvana and Dobrić, Silva and Mimica-Dukić, Neda and Simin, Nataša and Kukić, Jelena and Niketić, Marjan", year = "2008", abstract = "The present study investigated the antiinflammatory, gastroprotective and antioxidant activities of a CH(2)Cl(2) extract of western Balkan endemic Hieracium gymnocephalum Griseb. ex Pant. (Compositae). The carrageenan-induced rat paw oedema test was used as an experimental model for screening the antiinflammatory activity. The extract was administrated p.o. in doses of 25, 50, 100 and 200 mg/kg to rats and its effects compared with indomethacin, used p.o. as a reference drug. The results showed that the investigated extract reduced the oedema in a concentration-dependent manner. The obtained antiinflammatory effect was 5.9%, 11.7%, 31.2% and 44.1% at doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 100 mg/kg. Indomethacin had a strong antiinflammatory effect of 73.4% at a dose of 8 mg/kg, but caused large gastric lesions. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the and inflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The antioxidant activity of the H. gymnocephalum extract, investigated using DPPH radical assay, OH-radical assay and TBA-test, was not substantial. Copyright", publisher = "John Wiley & Sons Ltd, Chichester", journal = "Phytotherapy Research", title = "The Antiinflammatory, Gastroprotective and Antioxidant Activities of Hieracium gymnocephalum Extract", volume = "22", number = "11", pages = "1548-1551", doi = "10.1002/ptr.2485" }
Petrović, S., Dobrić, S., Mimica-Dukić, N., Simin, N., Kukić, J.,& Niketić, M.. (2008). The Antiinflammatory, Gastroprotective and Antioxidant Activities of Hieracium gymnocephalum Extract. in Phytotherapy Research John Wiley & Sons Ltd, Chichester., 22(11), 1548-1551. https://doi.org/10.1002/ptr.2485
Petrović S, Dobrić S, Mimica-Dukić N, Simin N, Kukić J, Niketić M. The Antiinflammatory, Gastroprotective and Antioxidant Activities of Hieracium gymnocephalum Extract. in Phytotherapy Research. 2008;22(11):1548-1551. doi:10.1002/ptr.2485 .
Petrović, Silvana, Dobrić, Silva, Mimica-Dukić, Neda, Simin, Nataša, Kukić, Jelena, Niketić, Marjan, "The Antiinflammatory, Gastroprotective and Antioxidant Activities of Hieracium gymnocephalum Extract" in Phytotherapy Research, 22, no. 11 (2008):1548-1551, https://doi.org/10.1002/ptr.2485 . .