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The Antiinflammatory, Gastroprotective and Antioxidant Activities of Hieracium gymnocephalum Extract

Само за регистроване кориснике
2008
Аутори
Petrović, Silvana
Dobrić, Silva
Mimica-Dukić, Neda
Simin, Nataša
Kukić, Jelena
Niketić, Marjan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документу
Апстракт
The present study investigated the antiinflammatory, gastroprotective and antioxidant activities of a CH(2)Cl(2) extract of western Balkan endemic Hieracium gymnocephalum Griseb. ex Pant. (Compositae). The carrageenan-induced rat paw oedema test was used as an experimental model for screening the antiinflammatory activity. The extract was administrated p.o. in doses of 25, 50, 100 and 200 mg/kg to rats and its effects compared with indomethacin, used p.o. as a reference drug. The results showed that the investigated extract reduced the oedema in a concentration-dependent manner. The obtained antiinflammatory effect was 5.9%, 11.7%, 31.2% and 44.1% at doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 100 mg/kg. Indomethacin had a strong antiinflammatory effect of 73.4% at a dose of 8 mg/kg, but caused large gastric lesions. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the and inflamm...atory effect was slightly enhanced, but the gastric lesions were significantly reduced. The antioxidant activity of the H. gymnocephalum extract, investigated using DPPH radical assay, OH-radical assay and TBA-test, was not substantial. Copyright

Кључне речи:
Hieracium gymnocephalum / anti-inflammatory activity / gastroprotective activity / antioxidant activity
Извор:
Phytotherapy Research, 2008, 22, 11, 1548-1551
Издавач:
  • John Wiley & Sons Ltd, Chichester
Финансирање / пројекти:
  • Испитивање лековитог потенцијала биљака: морфолошка, хемијска и фармаколошка карактеризација (RS-143012)

DOI: 10.1002/ptr.2485

ISSN: 0951-418X

PubMed: 18814212

WoS: 000261124900024

Scopus: 2-s2.0-57349167447
[ Google Scholar ]
13
9
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1037
Колекције
  • Radovi istraživača / Researchers’ publications
Институција/група
Pharmacy
TY  - JOUR
AU  - Petrović, Silvana
AU  - Dobrić, Silva
AU  - Mimica-Dukić, Neda
AU  - Simin, Nataša
AU  - Kukić, Jelena
AU  - Niketić, Marjan
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1037
AB  - The present study investigated the antiinflammatory, gastroprotective and antioxidant activities of a CH(2)Cl(2) extract of western Balkan endemic Hieracium gymnocephalum Griseb. ex Pant. (Compositae). The carrageenan-induced rat paw oedema test was used as an experimental model for screening the antiinflammatory activity. The extract was administrated p.o. in doses of 25, 50, 100 and 200 mg/kg to rats and its effects compared with indomethacin, used p.o. as a reference drug. The results showed that the investigated extract reduced the oedema in a concentration-dependent manner. The obtained antiinflammatory effect was 5.9%, 11.7%, 31.2% and 44.1% at doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 100 mg/kg. Indomethacin had a strong antiinflammatory effect of 73.4% at a dose of 8 mg/kg, but caused large gastric lesions. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the and inflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The antioxidant activity of the H. gymnocephalum extract, investigated using DPPH radical assay, OH-radical assay and TBA-test, was not substantial. Copyright
PB  - John Wiley & Sons Ltd, Chichester
T2  - Phytotherapy Research
T1  - The Antiinflammatory, Gastroprotective and Antioxidant Activities of Hieracium gymnocephalum Extract
VL  - 22
IS  - 11
SP  - 1548
EP  - 1551
DO  - 10.1002/ptr.2485
ER  - 
@article{
author = "Petrović, Silvana and Dobrić, Silva and Mimica-Dukić, Neda and Simin, Nataša and Kukić, Jelena and Niketić, Marjan",
year = "2008",
abstract = "The present study investigated the antiinflammatory, gastroprotective and antioxidant activities of a CH(2)Cl(2) extract of western Balkan endemic Hieracium gymnocephalum Griseb. ex Pant. (Compositae). The carrageenan-induced rat paw oedema test was used as an experimental model for screening the antiinflammatory activity. The extract was administrated p.o. in doses of 25, 50, 100 and 200 mg/kg to rats and its effects compared with indomethacin, used p.o. as a reference drug. The results showed that the investigated extract reduced the oedema in a concentration-dependent manner. The obtained antiinflammatory effect was 5.9%, 11.7%, 31.2% and 44.1% at doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 100 mg/kg. Indomethacin had a strong antiinflammatory effect of 73.4% at a dose of 8 mg/kg, but caused large gastric lesions. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the and inflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The antioxidant activity of the H. gymnocephalum extract, investigated using DPPH radical assay, OH-radical assay and TBA-test, was not substantial. Copyright",
publisher = "John Wiley & Sons Ltd, Chichester",
journal = "Phytotherapy Research",
title = "The Antiinflammatory, Gastroprotective and Antioxidant Activities of Hieracium gymnocephalum Extract",
volume = "22",
number = "11",
pages = "1548-1551",
doi = "10.1002/ptr.2485"
}
Petrović, S., Dobrić, S., Mimica-Dukić, N., Simin, N., Kukić, J.,& Niketić, M.. (2008). The Antiinflammatory, Gastroprotective and Antioxidant Activities of Hieracium gymnocephalum Extract. in Phytotherapy Research
John Wiley & Sons Ltd, Chichester., 22(11), 1548-1551.
https://doi.org/10.1002/ptr.2485
Petrović S, Dobrić S, Mimica-Dukić N, Simin N, Kukić J, Niketić M. The Antiinflammatory, Gastroprotective and Antioxidant Activities of Hieracium gymnocephalum Extract. in Phytotherapy Research. 2008;22(11):1548-1551.
doi:10.1002/ptr.2485 .
Petrović, Silvana, Dobrić, Silva, Mimica-Dukić, Neda, Simin, Nataša, Kukić, Jelena, Niketić, Marjan, "The Antiinflammatory, Gastroprotective and Antioxidant Activities of Hieracium gymnocephalum Extract" in Phytotherapy Research, 22, no. 11 (2008):1548-1551,
https://doi.org/10.1002/ptr.2485 . .

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