Show simple item record

dc.creatorPetrović, Silvana
dc.creatorDobrić, Silva
dc.creatorMimica-Dukić, Neda
dc.creatorSimin, Nataša
dc.creatorKukić, Jelena
dc.creatorNiketić, Marjan
dc.date.accessioned2019-09-02T11:12:32Z
dc.date.available2019-09-02T11:12:32Z
dc.date.issued2008
dc.identifier.issn0951-418X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1037
dc.description.abstractThe present study investigated the antiinflammatory, gastroprotective and antioxidant activities of a CH(2)Cl(2) extract of western Balkan endemic Hieracium gymnocephalum Griseb. ex Pant. (Compositae). The carrageenan-induced rat paw oedema test was used as an experimental model for screening the antiinflammatory activity. The extract was administrated p.o. in doses of 25, 50, 100 and 200 mg/kg to rats and its effects compared with indomethacin, used p.o. as a reference drug. The results showed that the investigated extract reduced the oedema in a concentration-dependent manner. The obtained antiinflammatory effect was 5.9%, 11.7%, 31.2% and 44.1% at doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 100 mg/kg. Indomethacin had a strong antiinflammatory effect of 73.4% at a dose of 8 mg/kg, but caused large gastric lesions. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the and inflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The antioxidant activity of the H. gymnocephalum extract, investigated using DPPH radical assay, OH-radical assay and TBA-test, was not substantial. Copyrighten
dc.publisherJohn Wiley & Sons Ltd, Chichester
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143012/RS//
dc.rightsrestrictedAccess
dc.sourcePhytotherapy Research
dc.subjectHieracium gymnocephalumen
dc.subjectanti-inflammatory activityen
dc.subjectgastroprotective activityen
dc.subjectantioxidant activityen
dc.titleThe Antiinflammatory, Gastroprotective and Antioxidant Activities of Hieracium gymnocephalum Extracten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПетровић, Силвана; Симин, Наташа; Кукић, Јелена; Мимица-Дукић, Неда; Никетић, Марјан; Добрић, Силва;
dc.citation.volume22
dc.citation.issue11
dc.citation.spage1548
dc.citation.epage1551
dc.citation.other22(11): 1548-1551
dc.citation.rankM22
dc.identifier.wos000261124900024
dc.identifier.doi10.1002/ptr.2485
dc.identifier.pmid18814212
dc.identifier.scopus2-s2.0-57349167447
dc.identifier.rcubconv_2090
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record