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A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol

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2008
1039.pdf (259.8Kb)
Authors
Gojković-Bukarica, Ljiljana
Novaković, Aleksandra
Kanjuh, Vladimir
Bumbasirević, Marko
Lesić, Aleksandar
Heinle, Helmut
Article (Published version)
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Abstract
Recently it has been suggested that resveratrol relaxes different isolated arteries. The present study addressed the question whether different ion channels are involved in the endothelium-independent mechanism of vasodilatation induced by resveratrol. For that purpose, we tested the action of resveratrol on the rat mesenteric artery without endothelium. Resveratrol induced con centration-dependent relaxation of rat mesenteric artery. Among the K+-channel blockers, 4-amynopiridine (4-AP) moderately antagonized the resveratrol-induced relaxation, while glibendamide, tetraethylammonium chloride, charybdotoxin, margatoxin, and barium chloride did not inhibit resveratrol-induced vasorelaxation. In rings, precontracted with 100 mM K+, the relaxant responses to resveratrol were highly significantly shifted to the right compared to those obtained in rings precontracted with phenylephrine, but resveratrol-induced maximal relaxation was only slightly affected. In order to minimize the influence... of K+ channels and voltage-gated Ca2+ channels (VGCCs) in vascular smooth muscle, the third contraction was made by 100 in M K- in the presence of nifedipine. The relaxant response to resveratrol was abolished. Thus, the mechanism of vasorelaxation induced by resveratrol probably involves activation of 4-AP-sensitive K+ channels. Its ability to completely relax the mesenteric artery precontracted with K+-rich solution suggests that K channel-independent mechanism(s) are involved in its vasorelaxant effect. It seems that interaction with VGCCs plays a part in this K+ channel-independent effect of resveratrol.

Keywords:
resveratrol / rat mesenteric artery / ion channel / vasorelaxation / K+ channel
Source:
Journal of Pharmacological Sciences, 2008, 108, 1, 124-130
Publisher:
  • Japanese Pharmacological Soc, Kyoto
Projects:
  • Ministry of Science and Technology (Serbia)
  • Karl & Lora Klein Foundation (Germany)

DOI: 10.1254/jphs.08128FP

ISSN: 1347-8613

PubMed: 18818483

WoS: 000259683400015

Scopus: 2-s2.0-52949145570
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1041
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Pharmacy

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