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dc.creatorGojković-Bukarica, Ljiljana
dc.creatorNovaković, Aleksandra
dc.creatorKanjuh, Vladimir
dc.creatorBumbasirević, Marko
dc.creatorLesić, Aleksandar
dc.creatorHeinle, Helmut
dc.date.accessioned2019-09-02T11:12:38Z
dc.date.available2019-09-02T11:12:38Z
dc.date.issued2008
dc.identifier.issn1347-8613
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1041
dc.description.abstractRecently it has been suggested that resveratrol relaxes different isolated arteries. The present study addressed the question whether different ion channels are involved in the endothelium-independent mechanism of vasodilatation induced by resveratrol. For that purpose, we tested the action of resveratrol on the rat mesenteric artery without endothelium. Resveratrol induced con centration-dependent relaxation of rat mesenteric artery. Among the K+-channel blockers, 4-amynopiridine (4-AP) moderately antagonized the resveratrol-induced relaxation, while glibendamide, tetraethylammonium chloride, charybdotoxin, margatoxin, and barium chloride did not inhibit resveratrol-induced vasorelaxation. In rings, precontracted with 100 mM K+, the relaxant responses to resveratrol were highly significantly shifted to the right compared to those obtained in rings precontracted with phenylephrine, but resveratrol-induced maximal relaxation was only slightly affected. In order to minimize the influence of K+ channels and voltage-gated Ca2+ channels (VGCCs) in vascular smooth muscle, the third contraction was made by 100 in M K- in the presence of nifedipine. The relaxant response to resveratrol was abolished. Thus, the mechanism of vasorelaxation induced by resveratrol probably involves activation of 4-AP-sensitive K+ channels. Its ability to completely relax the mesenteric artery precontracted with K+-rich solution suggests that K channel-independent mechanism(s) are involved in its vasorelaxant effect. It seems that interaction with VGCCs plays a part in this K+ channel-independent effect of resveratrol.en
dc.publisherJapanese Pharmacological Soc, Kyoto
dc.relationMinistry of Science and Technology (Serbia)
dc.relationKarl & Lora Klein Foundation (Germany)
dc.rightsopenAccess
dc.sourceJournal of Pharmacological Sciences
dc.subjectresveratrolen
dc.subjectrat mesenteric arteryen
dc.subjection channelen
dc.subjectvasorelaxationen
dc.subjectK+ channelen
dc.titleA role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrolen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractХеинле, Хелмут; Новаковић, Aлександра; Гојковић-Букарица, Љиљана; Лесић, Aлександар; Бумбасиревић, Марко; Кањух, Владимир;
dc.citation.volume108
dc.citation.issue1
dc.citation.spage124
dc.citation.epage130
dc.citation.other108(1): 124-130
dc.citation.rankM22
dc.identifier.wos000259683400015
dc.identifier.doi10.1254/jphs.08128FP
dc.identifier.pmid18818483
dc.identifier.scopus2-s2.0-52949145570
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/34/1039.pdf
dc.identifier.rcubconv_2077
dc.type.versionpublishedVersion


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