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The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients

Authorized Users Only
2008
Authors
Stefanović, Aleksandra
Kotur-Stevuljević, Jelena
Spasić, Slavica
Bogavac-Stanojević, Nataša
Bujisić, Nada
Article (Published version)
Metadata
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Abstract
The aim of this study was to determinate both the oxidative stress/anti-oxidative defense status and the concentration of leptin in obese, overweight and normal weight type 2 diabetes mellitus patients to seek possible association between oxidative stress and hyperleptinemia. Oxidative stress status parameters [thiobarbituric acid-reacting substances (TBARS), superoxide anion (O-2(center dot-)), superoxide dismutase (SOD) activity and total sulphydryl groups] and the concentration of leptin were measured in 312 subjects (178 patients and in 134 control subjects). Obese patients had a significantly higher concentration of leptin compared to obese subjects in the control population (P lt 0.001). They also had significantly higher plasma concentrations of TBARS, O-2(center dot-) and SOD activity in combination with a lower sulphydryl group concentration when compared to control subjects. Obese patients had significantly higher concentrations of both TBARS and O-2(center dot-) and increa...sed SOD activity compared to normal weight patients. The odds ratio for the degree of association between oxidative stress status parameters and hyperleptinemia was strongest for TBARS [odds ratio 2.66, 95% CI (1.02-6.94), P = 0.045]. The observed positive correlation between TBARS and leptin (p = 0.29, P lt 0.01) in obese patients suggests that increased oxidative stress and hyperleptinemia, both consequences of obesity, may play a role in type 2 diabetes mellitus development.

Keywords:
diabetes / leptin / oxidative stress / obesity
Source:
Diabetes Research and Clinical Practice, 2008, 79, 1, 156-163
Publisher:
  • Elsevier Ireland Ltd, Clare
Funding / projects:
  • Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-145036)

DOI: 10.1016/j.diabres.2007.07.019

ISSN: 0168-8227

PubMed: 17850913

WoS: 000253031800027

Scopus: 2-s2.0-37549033896
[ Google Scholar ]
79
65
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1043
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
AU  - Bogavac-Stanojević, Nataša
AU  - Bujisić, Nada
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1043
AB  - The aim of this study was to determinate both the oxidative stress/anti-oxidative defense status and the concentration of leptin in obese, overweight and normal weight type 2 diabetes mellitus patients to seek possible association between oxidative stress and hyperleptinemia. Oxidative stress status parameters [thiobarbituric acid-reacting substances (TBARS), superoxide anion (O-2(center dot-)), superoxide dismutase (SOD) activity and total sulphydryl groups] and the concentration of leptin were measured in 312 subjects (178 patients and in 134 control subjects). Obese patients had a significantly higher concentration of leptin compared to obese subjects in the control population (P  lt  0.001). They also had significantly higher plasma concentrations of TBARS, O-2(center dot-) and SOD activity in combination with a lower sulphydryl group concentration when compared to control subjects. Obese patients had significantly higher concentrations of both TBARS and O-2(center dot-) and increased SOD activity compared to normal weight patients. The odds ratio for the degree of association between oxidative stress status parameters and hyperleptinemia was strongest for TBARS [odds ratio 2.66, 95% CI (1.02-6.94), P = 0.045]. The observed positive correlation between TBARS and leptin (p = 0.29, P  lt  0.01) in obese patients suggests that increased oxidative stress and hyperleptinemia, both consequences of obesity, may play a role in type 2 diabetes mellitus development.
PB  - Elsevier Ireland Ltd, Clare
T2  - Diabetes Research and Clinical Practice
T1  - The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients
VL  - 79
IS  - 1
SP  - 156
EP  - 163
DO  - 10.1016/j.diabres.2007.07.019
ER  - 
@article{
author = "Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Spasić, Slavica and Bogavac-Stanojević, Nataša and Bujisić, Nada",
year = "2008",
abstract = "The aim of this study was to determinate both the oxidative stress/anti-oxidative defense status and the concentration of leptin in obese, overweight and normal weight type 2 diabetes mellitus patients to seek possible association between oxidative stress and hyperleptinemia. Oxidative stress status parameters [thiobarbituric acid-reacting substances (TBARS), superoxide anion (O-2(center dot-)), superoxide dismutase (SOD) activity and total sulphydryl groups] and the concentration of leptin were measured in 312 subjects (178 patients and in 134 control subjects). Obese patients had a significantly higher concentration of leptin compared to obese subjects in the control population (P  lt  0.001). They also had significantly higher plasma concentrations of TBARS, O-2(center dot-) and SOD activity in combination with a lower sulphydryl group concentration when compared to control subjects. Obese patients had significantly higher concentrations of both TBARS and O-2(center dot-) and increased SOD activity compared to normal weight patients. The odds ratio for the degree of association between oxidative stress status parameters and hyperleptinemia was strongest for TBARS [odds ratio 2.66, 95% CI (1.02-6.94), P = 0.045]. The observed positive correlation between TBARS and leptin (p = 0.29, P  lt  0.01) in obese patients suggests that increased oxidative stress and hyperleptinemia, both consequences of obesity, may play a role in type 2 diabetes mellitus development.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Diabetes Research and Clinical Practice",
title = "The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients",
volume = "79",
number = "1",
pages = "156-163",
doi = "10.1016/j.diabres.2007.07.019"
}
Stefanović, A., Kotur-Stevuljević, J., Spasić, S., Bogavac-Stanojević, N.,& Bujisić, N.. (2008). The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients. in Diabetes Research and Clinical Practice
Elsevier Ireland Ltd, Clare., 79(1), 156-163.
https://doi.org/10.1016/j.diabres.2007.07.019
Stefanović A, Kotur-Stevuljević J, Spasić S, Bogavac-Stanojević N, Bujisić N. The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients. in Diabetes Research and Clinical Practice. 2008;79(1):156-163.
doi:10.1016/j.diabres.2007.07.019 .
Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Spasić, Slavica, Bogavac-Stanojević, Nataša, Bujisić, Nada, "The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients" in Diabetes Research and Clinical Practice, 79, no. 1 (2008):156-163,
https://doi.org/10.1016/j.diabres.2007.07.019 . .

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