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dc.creatorStefanović, Aleksandra
dc.creatorKotur-Stevuljević, Jelena
dc.creatorSpasić, Slavica
dc.creatorBogavac-Stanojević, Nataša
dc.creatorBujisić, Nada
dc.date.accessioned2019-09-02T11:12:43Z
dc.date.available2019-09-02T11:12:43Z
dc.date.issued2008
dc.identifier.issn0168-8227
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1043
dc.description.abstractThe aim of this study was to determinate both the oxidative stress/anti-oxidative defense status and the concentration of leptin in obese, overweight and normal weight type 2 diabetes mellitus patients to seek possible association between oxidative stress and hyperleptinemia. Oxidative stress status parameters [thiobarbituric acid-reacting substances (TBARS), superoxide anion (O-2(center dot-)), superoxide dismutase (SOD) activity and total sulphydryl groups] and the concentration of leptin were measured in 312 subjects (178 patients and in 134 control subjects). Obese patients had a significantly higher concentration of leptin compared to obese subjects in the control population (P lt 0.001). They also had significantly higher plasma concentrations of TBARS, O-2(center dot-) and SOD activity in combination with a lower sulphydryl group concentration when compared to control subjects. Obese patients had significantly higher concentrations of both TBARS and O-2(center dot-) and increased SOD activity compared to normal weight patients. The odds ratio for the degree of association between oxidative stress status parameters and hyperleptinemia was strongest for TBARS [odds ratio 2.66, 95% CI (1.02-6.94), P = 0.045]. The observed positive correlation between TBARS and leptin (p = 0.29, P lt 0.01) in obese patients suggests that increased oxidative stress and hyperleptinemia, both consequences of obesity, may play a role in type 2 diabetes mellitus development.en
dc.publisherElsevier Ireland Ltd, Clare
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS//
dc.rightsrestrictedAccess
dc.sourceDiabetes Research and Clinical Practice
dc.subjectdiabetesen
dc.subjectleptinen
dc.subjectoxidative stressen
dc.subjectobesityen
dc.titleThe influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБогавац-Станојевић, Наташа; Котур-Стевуљевић, Јелена; Стефановић, Aлександра; Спасић, Славица; Бујисић, Нада;
dc.citation.volume79
dc.citation.issue1
dc.citation.spage156
dc.citation.epage163
dc.citation.other79(1): 156-163
dc.citation.rankM23
dc.identifier.wos000253031800027
dc.identifier.doi10.1016/j.diabres.2007.07.019
dc.identifier.pmid17850913
dc.identifier.scopus2-s2.0-37549033896
dc.identifier.rcubconv_1956
dc.type.versionpublishedVersion


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