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The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients
dc.creator | Stefanović, Aleksandra | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Spasić, Slavica | |
dc.creator | Bogavac-Stanojević, Nataša | |
dc.creator | Bujisić, Nada | |
dc.date.accessioned | 2019-09-02T11:12:43Z | |
dc.date.available | 2019-09-02T11:12:43Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0168-8227 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1043 | |
dc.description.abstract | The aim of this study was to determinate both the oxidative stress/anti-oxidative defense status and the concentration of leptin in obese, overweight and normal weight type 2 diabetes mellitus patients to seek possible association between oxidative stress and hyperleptinemia. Oxidative stress status parameters [thiobarbituric acid-reacting substances (TBARS), superoxide anion (O-2(center dot-)), superoxide dismutase (SOD) activity and total sulphydryl groups] and the concentration of leptin were measured in 312 subjects (178 patients and in 134 control subjects). Obese patients had a significantly higher concentration of leptin compared to obese subjects in the control population (P lt 0.001). They also had significantly higher plasma concentrations of TBARS, O-2(center dot-) and SOD activity in combination with a lower sulphydryl group concentration when compared to control subjects. Obese patients had significantly higher concentrations of both TBARS and O-2(center dot-) and increased SOD activity compared to normal weight patients. The odds ratio for the degree of association between oxidative stress status parameters and hyperleptinemia was strongest for TBARS [odds ratio 2.66, 95% CI (1.02-6.94), P = 0.045]. The observed positive correlation between TBARS and leptin (p = 0.29, P lt 0.01) in obese patients suggests that increased oxidative stress and hyperleptinemia, both consequences of obesity, may play a role in type 2 diabetes mellitus development. | en |
dc.publisher | Elsevier Ireland Ltd, Clare | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS// | |
dc.rights | restrictedAccess | |
dc.source | Diabetes Research and Clinical Practice | |
dc.subject | diabetes | en |
dc.subject | leptin | en |
dc.subject | oxidative stress | en |
dc.subject | obesity | en |
dc.title | The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Богавац-Станојевић, Наташа; Котур-Стевуљевић, Јелена; Стефановић, Aлександра; Спасић, Славица; Бујисић, Нада; | |
dc.citation.volume | 79 | |
dc.citation.issue | 1 | |
dc.citation.spage | 156 | |
dc.citation.epage | 163 | |
dc.citation.other | 79(1): 156-163 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000253031800027 | |
dc.identifier.doi | 10.1016/j.diabres.2007.07.019 | |
dc.identifier.pmid | 17850913 | |
dc.identifier.scopus | 2-s2.0-37549033896 | |
dc.type.version | publishedVersion |