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Spectrophotometric determination of bifonazole in pharmaceutical formulations using bromphenol blue

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Authors
Vladimirov, S
Brborić, Jasmina
Agbaba, Danica
Zivanov, D
Stakić, D.Ž
Article (Published version)
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Abstract
A sensitive spectrophotometric method for the determination of bifonazole is described. Bifonazole was treated with bromphenol blue (BPB) in the presence of citrate buffer (pH 2.5; μ = 0.23). The formed ion-pair complex was extracted with chloroform. By using spectrophotometric measurements, Job's and Bent-French's methods, it was found that bifonazole and BPB formed an ion-pair complex with the absorption maximum at 414 nm (molecular ratio of bifonazole BPB = 1:2) and molar absorptivity 2.23 x 104 L mol-1 cm-1. Beer's law was obeyed up to 2.5 μg ml-1. The proposed method was applied for determination of bifonazole in pharmaceutical formulations. Statistical analysis of the results obtained showed that the proposed method has good reproducibility and precision.
Source:
Farmaco, 1993, 48, 7, 1007-1015

ISSN: 0014-827X

Scopus: 2-s2.0-0027254555
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http://farfar.pharmacy.bg.ac.rs/handle/123456789/105
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  • Radovi istraživača / Researchers’ publications
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Pharmacy

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