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Spectrophotometric determination of bifonazole in pharmaceutical formulations using bromphenol blue

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Authors
Vladimirov, S
Brborić, Jasmina
Agbaba, Danica
Zivanov, D
Stakić, D.Ž
Article (Published version)
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Abstract
A sensitive spectrophotometric method for the determination of bifonazole is described. Bifonazole was treated with bromphenol blue (BPB) in the presence of citrate buffer (pH 2.5; μ = 0.23). The formed ion-pair complex was extracted with chloroform. By using spectrophotometric measurements, Job's and Bent-French's methods, it was found that bifonazole and BPB formed an ion-pair complex with the absorption maximum at 414 nm (molecular ratio of bifonazole BPB = 1:2) and molar absorptivity 2.23 x 104 L mol-1 cm-1. Beer's law was obeyed up to 2.5 μg ml-1. The proposed method was applied for determination of bifonazole in pharmaceutical formulations. Statistical analysis of the results obtained showed that the proposed method has good reproducibility and precision.
Source:
Farmaco, 1993, 48, 7, 1007-1015

ISSN: 0014-827X

Scopus: 2-s2.0-0027254555
[ Google Scholar ]
6
Handle
https://hdl.handle.net/21.15107/rcub_farfar_105
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/105
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Vladimirov, S
AU  - Brborić, Jasmina
AU  - Agbaba, Danica
AU  - Zivanov, D
AU  - Stakić, D.Ž
PY  - 1993
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/105
AB  - A sensitive spectrophotometric method for the determination of bifonazole is described. Bifonazole was treated with bromphenol blue (BPB) in the presence of citrate buffer (pH 2.5; μ = 0.23). The formed ion-pair complex was extracted with chloroform. By using spectrophotometric measurements, Job's and Bent-French's methods, it was found that bifonazole and BPB formed an ion-pair complex with the absorption maximum at 414 nm (molecular ratio of bifonazole BPB = 1:2) and molar absorptivity 2.23 x 104 L mol-1 cm-1. Beer's law was obeyed up to 2.5 μg ml-1. The proposed method was applied for determination of bifonazole in pharmaceutical formulations. Statistical analysis of the results obtained showed that the proposed method has good reproducibility and precision.
T2  - Farmaco
T1  - Spectrophotometric determination of bifonazole in pharmaceutical formulations using bromphenol blue
VL  - 48
IS  - 7
SP  - 1007
EP  - 1015
UR  - https://hdl.handle.net/21.15107/rcub_farfar_105
ER  - 
@article{
author = "Vladimirov, S and Brborić, Jasmina and Agbaba, Danica and Zivanov, D and Stakić, D.Ž",
year = "1993",
abstract = "A sensitive spectrophotometric method for the determination of bifonazole is described. Bifonazole was treated with bromphenol blue (BPB) in the presence of citrate buffer (pH 2.5; μ = 0.23). The formed ion-pair complex was extracted with chloroform. By using spectrophotometric measurements, Job's and Bent-French's methods, it was found that bifonazole and BPB formed an ion-pair complex with the absorption maximum at 414 nm (molecular ratio of bifonazole BPB = 1:2) and molar absorptivity 2.23 x 104 L mol-1 cm-1. Beer's law was obeyed up to 2.5 μg ml-1. The proposed method was applied for determination of bifonazole in pharmaceutical formulations. Statistical analysis of the results obtained showed that the proposed method has good reproducibility and precision.",
journal = "Farmaco",
title = "Spectrophotometric determination of bifonazole in pharmaceutical formulations using bromphenol blue",
volume = "48",
number = "7",
pages = "1007-1015",
url = "https://hdl.handle.net/21.15107/rcub_farfar_105"
}
Vladimirov, S., Brborić, J., Agbaba, D., Zivanov, D.,& Stakić, D.Ž. (1993). Spectrophotometric determination of bifonazole in pharmaceutical formulations using bromphenol blue. in Farmaco, 48(7), 1007-1015.
https://hdl.handle.net/21.15107/rcub_farfar_105
Vladimirov S, Brborić J, Agbaba D, Zivanov D, Stakić D. Spectrophotometric determination of bifonazole in pharmaceutical formulations using bromphenol blue. in Farmaco. 1993;48(7):1007-1015.
https://hdl.handle.net/21.15107/rcub_farfar_105 .
Vladimirov, S, Brborić, Jasmina, Agbaba, Danica, Zivanov, D, Stakić, D.Ž, "Spectrophotometric determination of bifonazole in pharmaceutical formulations using bromphenol blue" in Farmaco, 48, no. 7 (1993):1007-1015,
https://hdl.handle.net/21.15107/rcub_farfar_105 .

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