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Age-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholamines

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2008
Authors
Leposavić, Gordana
Perišić, Milica
Article (Published version)
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Abstract
The present review summarizes recent data on age-related thymic changes termed thymic involution, and highlights the putative role of perturbances in extrathymical and, possibly, intrathymical production of gonadal steroids and catecholamines in this process. Thymic involution has been envisaged as an extremely complex process involving multifactorial mechanisms along the bone marrow-thymic axis that accounts for the major manifestations of immunosenescence. These mechanisms include basic cell aging processes (for example, cell replication and programmed cell death) and processes unique to the immune system (such as generation of the T cell receptor repertoire and control of potentially autoreactive cells). Given that the onset of age-associated thymic involution coincides with the rise in gonadal steroid levels at puberty, a causal link between these events has been suggested. It has been shown that: (1) peripubertal gonadectomy causes substantial decrease in the level of noradrenalin...e in adult male and female thymus and (2) catecholamines, acting via alpha- and beta-adrenoceptor, produce suppressive effects on the thymic cellularity and production of both effector and regulatory T cells. Furthermore, the possibility that gonadal steroids contribute to thymic involution is discussed in this paper. In light of recent data indicating that effects of gonadal hormone deprivation on the thymic cellularity and function are long lasting but transitory, a putative role for the intrathymic sex steroid/catecholamine production in assuring the organ involution, under conditions of their limited supply by extrathymic sources, is also considered. Copyright

Keywords:
Thymus / Involution / Thymopoiesis / Sex steroids / Catecholamines
Source:
NeuroImmunoModulation, 2008, 15, 4-6, 290-322
Publisher:
  • Karger, Basel
Projects:
  • Neuroendokrina modulacija imunskog odgovora: uloga simpato-adrenomedularnog sistema (RS-145049)

DOI: 10.1159/000156473

ISSN: 1021-7401

PubMed: 19047807

WoS: 000261564000010

Scopus: 2-s2.0-57149085680
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1051
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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