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dc.creatorMalenović, Anđelija
dc.creatorJančić-Stojanović, Biljana
dc.creatorMedenica, Mirjana
dc.creatorIvanović, D.
dc.date.accessioned2019-09-02T11:13:07Z
dc.date.available2019-09-02T11:13:07Z
dc.date.issued2008
dc.identifier.issn1233-2356
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1058
dc.description.abstractThis paper reports development and validation of a new microemulsion liquid chromatographic (MELC) method for rapid screening of simvastatin and simvastatin acid in human plasma. Plasma samples were injected directly into the HPLC system after appropriate sample dilution with mobile phase. Separations were performed on a 4.6 mm x 150 mm, 5-mu m particle, C-18 column, with UV detection at 238 nm. The mobile phase was 0.5% (w/v) diisopropyl ether, 1.0% (w/v) sodium dodecylsulphate (SDS), 4.0% (w/v) n-butanol, and 94.5% (w/w) aqueous 25 mM disodium hydrogen phosphate, pH 7.0, at a flow rate of 1 mL min(-1). The method was evaluated according to criteria stated in FDA bioanalytical method validation guidance. The unique approach applied in this paper enables direct analysis of simvastatin and simvastatin acid, so the method can be used to obtain reliable results in a rapid and simple way.en
dc.publisherAkademiai Kiado Zrt, Budapest
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142077/RS//
dc.rightsrestrictedAccess
dc.sourceActa Chromatographica
dc.subjectmicroemulsion liquid chromatographyen
dc.subjecthuman plasmaen
dc.subjectsimvastatinen
dc.subjectactive metaboliteen
dc.titleMicroemulsion Liquid Chromatographic Screening of Simvastatin and its Active Metabolite in Human Plasmaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈанчић-Стојановић, Биљана; Меденица, Мирјана; Ивановић, Д.; Маленовић, Aнђелија;
dc.citation.volume20
dc.citation.issue4
dc.citation.spage595
dc.citation.epage607
dc.citation.other20(4): 595-607
dc.citation.rankM23
dc.identifier.wos000261707900006
dc.identifier.doi10.1556/AChrom.20.2008.4.6
dc.identifier.scopus2-s2.0-70450233608
dc.identifier.rcubconv_2097
dc.type.versionpublishedVersion


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