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Statistical Optimization of Reverse Phase High Performance Liquid Chromatography for the Analysis of Caffeine Paracetamol and its Degradation Product p-aminophenol
dc.creator | Crevar, Milkica | |
dc.creator | Ivković, Branka | |
dc.creator | Vladimirov, Sote | |
dc.creator | Kuntić, Vesna | |
dc.creator | Vujić, Zorica | |
dc.date.accessioned | 2019-09-02T11:13:15Z | |
dc.date.available | 2019-09-02T11:13:15Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 1318-0207 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1064 | |
dc.description.abstract | Paracetamol, analgoantipyretic and anti-inflammatory drug, is available in numerous pharmaceutical formulations in common combination with caffeine and some other drug substances. p-aminophenol is paracatamol's process-related impurity that also may be present in formulations containing paracetamol. This paper presents a RP-HPLC method for simultaneous determination of caffeine, paracetamol and p-aminophenol, using chromatographic system Hewlett Packard 1100 series. In defining optimal RP-HPLC chromatographic conditions for the separation of these three compounds, experimental design was applied. Completely separation was achieved using Zorbax Extend C18 column (150 mm x 4.6 mm, 5 mu m), with mobile phase consisting of methanol-phosphate buffer pH 6 (20:80 v/v), flow rate of 1 ml/min, and column temperature of 30 degrees C. UV detection was performed at 230 nm. | en |
dc.publisher | Slovensko Kemijsko Drustvo, Ljubljana | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142072/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Acta Chimica Slovenica | |
dc.subject | RP-HPLC | en |
dc.subject | caffeine | en |
dc.subject | paracetamol | en |
dc.subject | p-aminophenol | en |
dc.subject | statistical optimization | en |
dc.title | Statistical Optimization of Reverse Phase High Performance Liquid Chromatography for the Analysis of Caffeine Paracetamol and its Degradation Product p-aminophenol | en |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Вујић, Зорица; Ивковић, Бранка; Цревар, Милкица; Владимиров, Соте; Кунтић, Весна; | |
dc.citation.volume | 55 | |
dc.citation.issue | 3 | |
dc.citation.spage | 665 | |
dc.citation.epage | 670 | |
dc.citation.other | 55(3): 665-670 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000260058200031 | |
dc.identifier.scopus | 2-s2.0-54349094030 | |
dc.identifier.fulltext | http://farfar.pharmacy.bg.ac.rs/bitstream/id/11830/Statistical_Optimization_of_pub_2008.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_1064 | |
dc.type.version | publishedVersion |