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Effects of low, adequate and high dietary zinc intake on metabolic interactions between zinc, copper and iron in different mongolian gerbil tissues

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Authors
Cerović, Aleksandra
Miletić, Ivanka
Blagojević, Duško
Šobajić, Slađana
Vasiljevska, Milijana
Poznanić, Milica
Radusinović, M.
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Abstract
This study examined the influence of low, adequate and high dietary zinc intake on the growth and metabolic interactions between zinc, copper and iron in different Mongolian gerbil (Meriones unguiculatus) tissues. Animals were fed a basal diet (for 3 wk) containing a low-zinc level (8 mg/ kg diet, LZ-group), adequate zinc level (25 mg/kg diet, AZ-group) and saturated zinc level (38 mg/ kg diet, SZ-group). After comparing the body weight of gerbils, the present study demonstrated that the LZ-group (51.68 g +/- 3.35) showed growth retardation, contrary to the AZ- and SZ-groups (58.03 g +/- 2.18 and 62.35 g +/- 2.04, respectively). Concentrations of zinc in the liver, kidneys and testes in the LZ-group (41.28, 19.58, 22.55 mg/kg, respectively) were significantly lower than in the AZ-group (57.27, 23.73, 28.79 mg/kg, respectively) and the SZ-group (73.06, 30.07, 34.52 mg/kg, respectively). Results also showed that copper and iron concentrations in the kidney, heart and liver were significa...ntly higher in the LZ-group (Cu 11.45, 7.01, 7.95 mg/kg; Fe 116.19, 126.07, 299.47 mg/kg) than in the AZ-group (Cu 8.72, 5.6, 6.5 mg/kg; Fe 97.27, 97.27, 250.25 mg/kg) and the SZ-group (Cu 6.48, 4.15, 4.8 mg/kg; Fe 74.95, 77.95, 200.27 mg/kg). There was an increase of testis copper concentration in the LZ-group (4.9 mg/kg) compared to the AZ- and SZ-groups (3.99 and 3.05 mg/kg, respectively), and there was no significant difference in testis iron concentration between animals in different diet groups. These results showed that a low-zinc diet had negative effects on growth and the concentration of zinc in the kidneys, liver and testes. This also affected homeostasis of copper and iron by increasing its distribution in the kidneys, liver and heart tissue. However, in testes only copper concentration was increased.

Keywords:
homeostasis / Zn / Cu / Fe / growth / kidney / liver / heart and testis tissues
Source:
Acta Veterinaria Brno, 2008, 77, 1, 17-23
Publisher:
  • Veterinarni A Farmaceuticka Univerzita Brno, Brno

DOI: 10.2754/avb200877010017

ISSN: 0001-7213

WoS: 000255001500003

Scopus: 2-s2.0-42449119354
[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1069
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Cerović, Aleksandra
AU  - Miletić, Ivanka
AU  - Blagojević, Duško
AU  - Šobajić, Slađana
AU  - Vasiljevska, Milijana
AU  - Poznanić, Milica
AU  - Radusinović, M.
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1069
AB  - This study examined the influence of low, adequate and high dietary zinc intake on the growth and metabolic interactions between zinc, copper and iron in different Mongolian gerbil (Meriones unguiculatus) tissues. Animals were fed a basal diet (for 3 wk) containing a low-zinc level (8 mg/ kg diet, LZ-group), adequate zinc level (25 mg/kg diet, AZ-group) and saturated zinc level (38 mg/ kg diet, SZ-group). After comparing the body weight of gerbils, the present study demonstrated that the LZ-group (51.68 g +/- 3.35) showed growth retardation, contrary to the AZ- and SZ-groups (58.03 g +/- 2.18 and 62.35 g +/- 2.04, respectively). Concentrations of zinc in the liver, kidneys and testes in the LZ-group (41.28, 19.58, 22.55 mg/kg, respectively) were significantly lower than in the AZ-group (57.27, 23.73, 28.79 mg/kg, respectively) and the SZ-group (73.06, 30.07, 34.52 mg/kg, respectively). Results also showed that copper and iron concentrations in the kidney, heart and liver were significantly higher in the LZ-group (Cu 11.45, 7.01, 7.95 mg/kg; Fe 116.19, 126.07, 299.47 mg/kg) than in the AZ-group (Cu 8.72, 5.6, 6.5 mg/kg; Fe 97.27, 97.27, 250.25 mg/kg) and the SZ-group (Cu 6.48, 4.15, 4.8 mg/kg; Fe 74.95, 77.95, 200.27 mg/kg). There was an increase of testis copper concentration in the LZ-group (4.9 mg/kg) compared to the AZ- and SZ-groups (3.99 and 3.05 mg/kg, respectively), and there was no significant difference in testis iron concentration between animals in different diet groups. These results showed that a low-zinc diet had negative effects on growth and the concentration of zinc in the kidneys, liver and testes. This also affected homeostasis of copper and iron by increasing its distribution in the kidneys, liver and heart tissue. However, in testes only copper concentration was increased.
PB  - Veterinarni A Farmaceuticka Univerzita Brno, Brno
T2  - Acta Veterinaria Brno
T1  - Effects of low, adequate and high dietary zinc intake on metabolic interactions between zinc, copper and iron in different mongolian gerbil tissues
VL  - 77
IS  - 1
SP  - 17
EP  - 23
DO  - 10.2754/avb200877010017
ER  - 
@article{
author = "Cerović, Aleksandra and Miletić, Ivanka and Blagojević, Duško and Šobajić, Slađana and Vasiljevska, Milijana and Poznanić, Milica and Radusinović, M.",
year = "2008",
abstract = "This study examined the influence of low, adequate and high dietary zinc intake on the growth and metabolic interactions between zinc, copper and iron in different Mongolian gerbil (Meriones unguiculatus) tissues. Animals were fed a basal diet (for 3 wk) containing a low-zinc level (8 mg/ kg diet, LZ-group), adequate zinc level (25 mg/kg diet, AZ-group) and saturated zinc level (38 mg/ kg diet, SZ-group). After comparing the body weight of gerbils, the present study demonstrated that the LZ-group (51.68 g +/- 3.35) showed growth retardation, contrary to the AZ- and SZ-groups (58.03 g +/- 2.18 and 62.35 g +/- 2.04, respectively). Concentrations of zinc in the liver, kidneys and testes in the LZ-group (41.28, 19.58, 22.55 mg/kg, respectively) were significantly lower than in the AZ-group (57.27, 23.73, 28.79 mg/kg, respectively) and the SZ-group (73.06, 30.07, 34.52 mg/kg, respectively). Results also showed that copper and iron concentrations in the kidney, heart and liver were significantly higher in the LZ-group (Cu 11.45, 7.01, 7.95 mg/kg; Fe 116.19, 126.07, 299.47 mg/kg) than in the AZ-group (Cu 8.72, 5.6, 6.5 mg/kg; Fe 97.27, 97.27, 250.25 mg/kg) and the SZ-group (Cu 6.48, 4.15, 4.8 mg/kg; Fe 74.95, 77.95, 200.27 mg/kg). There was an increase of testis copper concentration in the LZ-group (4.9 mg/kg) compared to the AZ- and SZ-groups (3.99 and 3.05 mg/kg, respectively), and there was no significant difference in testis iron concentration between animals in different diet groups. These results showed that a low-zinc diet had negative effects on growth and the concentration of zinc in the kidneys, liver and testes. This also affected homeostasis of copper and iron by increasing its distribution in the kidneys, liver and heart tissue. However, in testes only copper concentration was increased.",
publisher = "Veterinarni A Farmaceuticka Univerzita Brno, Brno",
journal = "Acta Veterinaria Brno",
title = "Effects of low, adequate and high dietary zinc intake on metabolic interactions between zinc, copper and iron in different mongolian gerbil tissues",
volume = "77",
number = "1",
pages = "17-23",
doi = "10.2754/avb200877010017"
}
Cerović, A., Miletić, I., Blagojević, D., Šobajić, S., Vasiljevska, M., Poznanić, M.,& Radusinović, M.. (2008). Effects of low, adequate and high dietary zinc intake on metabolic interactions between zinc, copper and iron in different mongolian gerbil tissues. in Acta Veterinaria Brno
Veterinarni A Farmaceuticka Univerzita Brno, Brno., 77(1), 17-23.
https://doi.org/10.2754/avb200877010017
Cerović A, Miletić I, Blagojević D, Šobajić S, Vasiljevska M, Poznanić M, Radusinović M. Effects of low, adequate and high dietary zinc intake on metabolic interactions between zinc, copper and iron in different mongolian gerbil tissues. in Acta Veterinaria Brno. 2008;77(1):17-23.
doi:10.2754/avb200877010017 .
Cerović, Aleksandra, Miletić, Ivanka, Blagojević, Duško, Šobajić, Slađana, Vasiljevska, Milijana, Poznanić, Milica, Radusinović, M., "Effects of low, adequate and high dietary zinc intake on metabolic interactions between zinc, copper and iron in different mongolian gerbil tissues" in Acta Veterinaria Brno, 77, no. 1 (2008):17-23,
https://doi.org/10.2754/avb200877010017 . .

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