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dc.creatorJuranić, Zorica
dc.creatorRadić, Jelena
dc.creatorKonić-Ristić, Aleksandra
dc.creatorJelić, Svetislav
dc.creatorMihaljević, Biljana
dc.creatorStanković, Ivan
dc.creatorMatković, Suzana
dc.creatorBesu, Irina
dc.creatorGavrilović, Dušica
dc.date.accessioned2019-09-02T11:13:24Z
dc.date.available2019-09-02T11:13:24Z
dc.date.issued2008
dc.identifier.issn1471-2237
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1071
dc.description.abstractBackground: Multiple myeloma (MM) is a clonal B-cell disorder with many immunological disturbances. The aim of this work was to assess whether some of food antigens contribute to the imbalance of immune response by screening the sera of MM patients for their immunoreactivity to food constituent gliadin, to tissue transglutaminase-2 (tTG-2) and to Ro/SSA antigen. Sera from 61 patients with MM in various stages of disease, before, or after some cycles of conventional therapy were analyzed by commercial Binding Site ELISA tests. The control group consisted of 50 healthy volunteers. Statistical analysis of data obtained was performed by Mann Whitney Test. Results: The higher serum IgA immunoreactivity to gliadin was found in 14/56 patients and in one of control people. The enhanced serum IgG immunoreactivity to gliadin was found in only two of tested patients and in two controls. The enhanced IgA immunoreactivity to tTG-2 was found in 10/49 patients' sera, while 4/45 patients had higher serum IgG immunoreactivity. The enhanced serum IgG immunoreactivity to RoSSA antigen was found in 9/47 analyzed MM patients' sera. Statistical analysis of data obtained revealed that only the levels of anti-tTG-2 IgA immunoreactivity in patients with MM were significantly higher than these obtained in healthy controls (P lt 0.02) Conclusion: Data obtained showed the existence of the enhanced serum immunoreactivity to gliadin, tTG-2 and Ro/SSA antigens in some patients with MM. These at least partially could contribute to the immunological imbalance frequently found in this disease.en
dc.publisherBMC, LONDON
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145006/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145055/RS//
dc.rightsopenAccess
dc.sourceBMC Immunology
dc.titleHumoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myelomaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈелић, Светислав; Михаљевић, Биљана; Матковић, Сузана; Станковић, Иван; Конић-Ристић, Aлександра; Гавриловић, Душица; Јуранић, Зорица; Бесу, Ирина; Радић, Јелена;
dc.citation.volume9
dc.citation.other9: -
dc.citation.rankM23
dc.identifier.wos000256602100001
dc.identifier.doi10.1186/1471-2172-9-22
dc.identifier.pmid18507842
dc.identifier.scopus2-s2.0-44949172461
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/57/1069.pdf
dc.type.versionpublishedVersion


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