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Column high-performance liquid chromatographic determination of norfloxacin and its main impurities in pharmaceuticals

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Authors
Miseljić, Branislava
Popović, Gordana
Agbaba, Danica
Marković, Slavko
Simonovska, Breda
Vovk, Irena
Article (Published version)
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Abstract
A gradient reversed-phase column high-performance liquid chromatographic method was developed for the detection and quantification of norfloxacin and its major impurities in norfloxacin-containing pharmaceuticals. Chromatographic separations were performed under the following experimental conditions: column, Zorbax SB RP-18 (5 mu m, 250 x 4.6 mm); injection volume, 20 mu L; mobile phase, 0.05 M NaH2PO4 (pH 2.5)-acetonitrile (87 + 13) for 16 min and (58 + 42) for 9 min (stepwise gradient); and flow rate, 1.3 mL/min. All analyses were performed at 25 degrees C, and the eluate was monitored at 275 nm using a diode array detector. Linearity (correlation coefficient = 0.999), recovery (99.3-101.8%), relative standard deviation (0.2-0.7%), and quantitation limit (0.12-0.47 mu g/mL) were evaluated and found to be satisfactory. The method is simple, rapid, and convenient for purity control of norfloxacin in both raw materials and dosage forms.
Source:
Journal of AOAC International, 2008, 91, 2, 332-338
Publisher:
  • AOAC Int, Gaithersburg

ISSN: 1060-3271

PubMed: 18476344

WoS: 000255088600010

Scopus: 2-s2.0-43449105354
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1077
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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