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dc.creatorMiseljić, Branislava
dc.creatorPopović, Gordana
dc.creatorAgbaba, Danica
dc.creatorMarković, Slavko
dc.creatorSimonovska, Breda
dc.creatorVovk, Irena
dc.date.accessioned2019-09-02T11:13:33Z
dc.date.available2019-09-02T11:13:33Z
dc.date.issued2008
dc.identifier.issn1060-3271
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1077
dc.description.abstractA gradient reversed-phase column high-performance liquid chromatographic method was developed for the detection and quantification of norfloxacin and its major impurities in norfloxacin-containing pharmaceuticals. Chromatographic separations were performed under the following experimental conditions: column, Zorbax SB RP-18 (5 mu m, 250 x 4.6 mm); injection volume, 20 mu L; mobile phase, 0.05 M NaH2PO4 (pH 2.5)-acetonitrile (87 + 13) for 16 min and (58 + 42) for 9 min (stepwise gradient); and flow rate, 1.3 mL/min. All analyses were performed at 25 degrees C, and the eluate was monitored at 275 nm using a diode array detector. Linearity (correlation coefficient = 0.999), recovery (99.3-101.8%), relative standard deviation (0.2-0.7%), and quantitation limit (0.12-0.47 mu g/mL) were evaluated and found to be satisfactory. The method is simple, rapid, and convenient for purity control of norfloxacin in both raw materials and dosage forms.en
dc.publisherAOAC Int, Gaithersburg
dc.rightsrestrictedAccess
dc.sourceJournal of AOAC International
dc.titleColumn high-performance liquid chromatographic determination of norfloxacin and its main impurities in pharmaceuticalsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПоповић, Гордана; Вовк, Ирена; Симоновска, Бреда; Марковић, Славко; Мисељић, Бранислава; Aгбаба, Даница;
dc.citation.volume91
dc.citation.issue2
dc.citation.spage332
dc.citation.epage338
dc.citation.other91(2): 332-338
dc.citation.rankM22
dc.identifier.wos000255088600010
dc.identifier.pmid18476344
dc.identifier.scopus2-s2.0-43449105354
dc.identifier.rcubconv_1984
dc.type.versionpublishedVersion


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