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Column high-performance liquid chromatographic determination of norfloxacin and its main impurities in pharmaceuticals
dc.creator | Miseljić, Branislava | |
dc.creator | Popović, Gordana | |
dc.creator | Agbaba, Danica | |
dc.creator | Marković, Slavko | |
dc.creator | Simonovska, Breda | |
dc.creator | Vovk, Irena | |
dc.date.accessioned | 2019-09-02T11:13:33Z | |
dc.date.available | 2019-09-02T11:13:33Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 1060-3271 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1077 | |
dc.description.abstract | A gradient reversed-phase column high-performance liquid chromatographic method was developed for the detection and quantification of norfloxacin and its major impurities in norfloxacin-containing pharmaceuticals. Chromatographic separations were performed under the following experimental conditions: column, Zorbax SB RP-18 (5 mu m, 250 x 4.6 mm); injection volume, 20 mu L; mobile phase, 0.05 M NaH2PO4 (pH 2.5)-acetonitrile (87 + 13) for 16 min and (58 + 42) for 9 min (stepwise gradient); and flow rate, 1.3 mL/min. All analyses were performed at 25 degrees C, and the eluate was monitored at 275 nm using a diode array detector. Linearity (correlation coefficient = 0.999), recovery (99.3-101.8%), relative standard deviation (0.2-0.7%), and quantitation limit (0.12-0.47 mu g/mL) were evaluated and found to be satisfactory. The method is simple, rapid, and convenient for purity control of norfloxacin in both raw materials and dosage forms. | en |
dc.publisher | AOAC Int, Gaithersburg | |
dc.rights | restrictedAccess | |
dc.source | Journal of AOAC International | |
dc.title | Column high-performance liquid chromatographic determination of norfloxacin and its main impurities in pharmaceuticals | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Поповић, Гордана; Вовк, Ирена; Симоновска, Бреда; Марковић, Славко; Мисељић, Бранислава; Aгбаба, Даница; | |
dc.citation.volume | 91 | |
dc.citation.issue | 2 | |
dc.citation.spage | 332 | |
dc.citation.epage | 338 | |
dc.citation.other | 91(2): 332-338 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000255088600010 | |
dc.identifier.pmid | 18476344 | |
dc.identifier.scopus | 2-s2.0-43449105354 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_1077 | |
dc.type.version | publishedVersion |
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