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dc.creatorPilipović, Ivan
dc.creatorVidić-Danković, Biljana
dc.creatorPerišić, Milica
dc.creatorRadojević, Katarina
dc.creatorČolić, Miodrag
dc.creatorTodorović, Vera
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T11:13:39Z
dc.date.available2019-09-02T11:13:39Z
dc.date.issued2008
dc.identifier.issn0165-5728
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1080
dc.description.abstractThe study was undertaken to explore whether there were: i) apart from neural and circulatory, some other sources of catecholamines (CAs) in rat thymus and ii) gender-specific differences in thymic CA levels, and if so to elucidate the role of sex steroids in this phenomenon. Tyrosine hydroxylase (TH) immunoreactivity was found in thymocytes and thymic epithelial cells (some of which showed morphological features of nurse cells). The density of CA-synthesizing cells was greater in male than in female rats. Noradrenaline (NA), but not dopamine (DA), was detected in thymocytes. NA and DA levels in thymi, and the NA level in thymocytes, were higher in male rats. To explore the Putative role of sex steroids in this dichotomy in the thymi of adult rats gonadectomized (Gx) or sham-Gx at the age of 30 days the density of TH+ cells and CA levels were measured. Gonadectomy abolished sexual dimorphism in the density of thymic TH+ cells (diminishing their density in male rats) and thymic CA levels (the NA levels were reduced in rats of both sexes and also the DA level in male rats). Therefore, it can be assumed that testicular and ovarian hormones control thymic NA and DA levels via different mechanisms. Moreover, in Gx rats, despite the decrease in the overall thymic NA level, an increase in the thymocyte NA level was found indicating that gonadal hormones exert differential effects on the NA level in distinct thymic cellular compartments.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Neuroimmunology
dc.subjectcatecholaminesen
dc.subjectimmunological sexual dimorphismen
dc.subjectgonadectomyen
dc.subjectthymusen
dc.subjectthymocytesen
dc.subjectthymic epithelial cellsen
dc.titleSexual dimorphism in the catecholamine-containing thymus microenvironment: A role for gonadal hormonesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЧолић, Миодраг; Радојевић, Катарина; Видић-Данковић, Биљана; Перишић, Милица; Лепосавић, Гордана; Пилиповић, Иван; Тодоровић, Вера;
dc.citation.volume195
dc.citation.issue1-2
dc.citation.spage7
dc.citation.epage20
dc.citation.other195(1-2): 7-20
dc.citation.rankM22
dc.identifier.wos000255802000002
dc.identifier.doi10.1016/j.jneuroim.2007.12.006
dc.identifier.pmid18262658
dc.identifier.scopus2-s2.0-41949091465
dc.identifier.rcubconv_1994
dc.type.versionpublishedVersion


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