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Does simultaneous determination of LDL and HDL particle size improve prediction of coronary artery disease risk?

Authorized Users Only
2008
Authors
Zeljković, Aleksandra
Spasojević-Kalimanovska, Vesna
Vekić, Jelena
Jelić-Ivanović, Zorana
Topić, Aleksandra
Bogavac-Stanojević, Nataša
Spasić, Slavica
Vujović, Ana
Kalimanovska-Oštrić, Dimitra
Article (Published version)
Metadata
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Abstract
Background Alterations in plasma lipoprotein subclass distribution affect the risk for coronary artery disease (CAD). However, it is unclear whether the determination of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) phenotypes may or may not improve the ability to predict CAD development. Methods Polyacrylamide gradient (3-31%) gel electrophoresis was used to simultaneously determine size and distribution of lipoprotein subclasses in 181 CAD patients and 178 controls. Results Mean LDL and HDL subclass sizes were significantly smaller in patients than in controls (p lt 0.001). Multivariate logistic regression analysis showed that small dense LDL particles were independent CAD risk predictors (OR = 2.867, p lt 0.01), even when adjusted for other traditional risk factors, while small HDL particles lost their significance after adjustment (OR = 2.071, p = 0.054). The area under the ROC curve for LDL (0.671) and HDL (0.643) particle size measurement demonstrated low c...linical accuracy when compared to the combination of traditional lipid risk factor measurements. Conclusions CAD is associated with the predominance of smaller LDL and HDL particles. However, simultaneous determination of these two lipoprotein phenotypes provides no additional power in discriminating CAD and non-CAD subjects, beyond that obtained by the traditional risk factors.

Keywords:
lipoprotein subclasses / CAD risk prediction
Source:
Clinical and Experimental Medicine, 2008, 8, 2, 109-116
Publisher:
  • Springer, New York
Funding / projects:
  • Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-145036)

DOI: 10.1007/s10238-008-0165-z

ISSN: 1591-8890

PubMed: 18618221

WoS: 000257022600008

Scopus: 2-s2.0-47349124839
[ Google Scholar ]
35
27
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1082
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Vekić, Jelena
AU  - Jelić-Ivanović, Zorana
AU  - Topić, Aleksandra
AU  - Bogavac-Stanojević, Nataša
AU  - Spasić, Slavica
AU  - Vujović, Ana
AU  - Kalimanovska-Oštrić, Dimitra
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1082
AB  - Background Alterations in plasma lipoprotein subclass distribution affect the risk for coronary artery disease (CAD). However, it is unclear whether the determination of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) phenotypes may or may not improve the ability to predict CAD development. Methods Polyacrylamide gradient (3-31%) gel electrophoresis was used to simultaneously determine size and distribution of lipoprotein subclasses in 181 CAD patients and 178 controls. Results Mean LDL and HDL subclass sizes were significantly smaller in patients than in controls (p  lt  0.001). Multivariate logistic regression analysis showed that small dense LDL particles were independent CAD risk predictors (OR = 2.867, p  lt  0.01), even when adjusted for other traditional risk factors, while small HDL particles lost their significance after adjustment (OR = 2.071, p = 0.054). The area under the ROC curve for LDL (0.671) and HDL (0.643) particle size measurement demonstrated low clinical accuracy when compared to the combination of traditional lipid risk factor measurements. Conclusions CAD is associated with the predominance of smaller LDL and HDL particles. However, simultaneous determination of these two lipoprotein phenotypes provides no additional power in discriminating CAD and non-CAD subjects, beyond that obtained by the traditional risk factors.
PB  - Springer, New York
T2  - Clinical and Experimental Medicine
T1  - Does simultaneous determination of LDL and HDL particle size improve prediction of coronary artery disease risk?
VL  - 8
IS  - 2
SP  - 109
EP  - 116
DO  - 10.1007/s10238-008-0165-z
ER  - 
@article{
author = "Zeljković, Aleksandra and Spasojević-Kalimanovska, Vesna and Vekić, Jelena and Jelić-Ivanović, Zorana and Topić, Aleksandra and Bogavac-Stanojević, Nataša and Spasić, Slavica and Vujović, Ana and Kalimanovska-Oštrić, Dimitra",
year = "2008",
abstract = "Background Alterations in plasma lipoprotein subclass distribution affect the risk for coronary artery disease (CAD). However, it is unclear whether the determination of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) phenotypes may or may not improve the ability to predict CAD development. Methods Polyacrylamide gradient (3-31%) gel electrophoresis was used to simultaneously determine size and distribution of lipoprotein subclasses in 181 CAD patients and 178 controls. Results Mean LDL and HDL subclass sizes were significantly smaller in patients than in controls (p  lt  0.001). Multivariate logistic regression analysis showed that small dense LDL particles were independent CAD risk predictors (OR = 2.867, p  lt  0.01), even when adjusted for other traditional risk factors, while small HDL particles lost their significance after adjustment (OR = 2.071, p = 0.054). The area under the ROC curve for LDL (0.671) and HDL (0.643) particle size measurement demonstrated low clinical accuracy when compared to the combination of traditional lipid risk factor measurements. Conclusions CAD is associated with the predominance of smaller LDL and HDL particles. However, simultaneous determination of these two lipoprotein phenotypes provides no additional power in discriminating CAD and non-CAD subjects, beyond that obtained by the traditional risk factors.",
publisher = "Springer, New York",
journal = "Clinical and Experimental Medicine",
title = "Does simultaneous determination of LDL and HDL particle size improve prediction of coronary artery disease risk?",
volume = "8",
number = "2",
pages = "109-116",
doi = "10.1007/s10238-008-0165-z"
}
Zeljković, A., Spasojević-Kalimanovska, V., Vekić, J., Jelić-Ivanović, Z., Topić, A., Bogavac-Stanojević, N., Spasić, S., Vujović, A.,& Kalimanovska-Oštrić, D.. (2008). Does simultaneous determination of LDL and HDL particle size improve prediction of coronary artery disease risk?. in Clinical and Experimental Medicine
Springer, New York., 8(2), 109-116.
https://doi.org/10.1007/s10238-008-0165-z
Zeljković A, Spasojević-Kalimanovska V, Vekić J, Jelić-Ivanović Z, Topić A, Bogavac-Stanojević N, Spasić S, Vujović A, Kalimanovska-Oštrić D. Does simultaneous determination of LDL and HDL particle size improve prediction of coronary artery disease risk?. in Clinical and Experimental Medicine. 2008;8(2):109-116.
doi:10.1007/s10238-008-0165-z .
Zeljković, Aleksandra, Spasojević-Kalimanovska, Vesna, Vekić, Jelena, Jelić-Ivanović, Zorana, Topić, Aleksandra, Bogavac-Stanojević, Nataša, Spasić, Slavica, Vujović, Ana, Kalimanovska-Oštrić, Dimitra, "Does simultaneous determination of LDL and HDL particle size improve prediction of coronary artery disease risk?" in Clinical and Experimental Medicine, 8, no. 2 (2008):109-116,
https://doi.org/10.1007/s10238-008-0165-z . .

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