Prikaz osnovnih podataka o dokumentu

dc.creatorHomšek, Irena
dc.creatorParojčić, Jelena
dc.creatorMitić, M.
dc.creatorSimić, Slobodanka
dc.creatorCvetković, Nebojša
dc.creatorĐurić, Zorica
dc.date.accessioned2019-09-02T11:13:45Z
dc.date.available2019-09-02T11:13:45Z
dc.date.issued2008
dc.identifier.issn1773-2247
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1083
dc.description.abstractThe aim of this study was to investigate the influence of experimental conditions on carbamazepine (CBZ) release from the two controlled-release (CR) tablet formulations with proven bioequivalence and to propose the universal release method which would be biorelevant, In vitro data were obtained in various release media using the USP apparatus II in order to assess their influence on CBZ release from CR tablets. An empirical correlation between in vivo plasma concentration data expressed as a fraction drug absorbed and the cumulative amount of in vitro release was established. The most complete release and highest level A correlation was observed by using the half change method (HCM) compared to other release methodologies tested. The results obtained indicate that the release test developed offers a promising in vitro tool for predicting the in vivo performance of CBZ CR tablets, ensuring batch to batch bioequivalence and verification of certain postapproval changes without the need for additional in vivo studies.en
dc.publisherEditions Sante, Paris
dc.rightsrestrictedAccess
dc.sourceJournal of Drug Delivery Science and Technology
dc.subjectcarbamazepineen
dc.subjectcontrolled-releaseen
dc.subjectBioequivalenceen
dc.subjectreleaseen
dc.subjectIVIVCen
dc.titleDevelopment of a drug release methodology for carbamazepine CR tablets based on bioequivalence evaluationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПаројчић, Јелена; Симић, Слободанка; Митић, М.; Цветковић, Небојша; Хомшек, Ирена; Ђурић, Зорица;
dc.citation.volume18
dc.citation.issue2
dc.citation.spage139
dc.citation.epage144
dc.citation.other18(2): 139-144
dc.citation.rankM23
dc.identifier.wos000255440300008
dc.identifier.doi10.1016/S1773-2247(08)50022-0
dc.identifier.scopus2-s2.0-41349114402
dc.type.versionpublishedVersion


Dokumenti

Thumbnail

Ovaj dokument se pojavljuje u sledećim kolekcijama

Prikaz osnovnih podataka o dokumentu