Приказ основних података о документу

dc.creatorTodorović, Tatjana
dc.creatorVujanović, Dragana
dc.creatorDozić, Ivan
dc.creatorPetković-Ćurčin, Aleksandra
dc.date.accessioned2019-09-02T11:13:49Z
dc.date.available2019-09-02T11:13:49Z
dc.date.issued2008
dc.identifier.issn0953-1424
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1087
dc.description.abstractLead manifests toxic effects in almost all organs and tissues, especially in: the nervous system, hematopoietic system, kidney and liver. This metal has a special affinity for deposition in hard tissue, i.e., bones and teeth. It is generally believed that the main mechanism of its toxicity relies on its interaction with bioelements, especially with Ca and Mg. This article analyses the influence of Pb poisoning on Ca and Mg content in hard tissues, (mandible, femur, teeth and skull) of female and young rats. Experiments were carried out on 60 female rats, AO breed, and on 80 of their young rats (offspring). Female rats were divided into three groups: the first one was a control group, the second one received 100 mg/kg Pb2+ kg b.wt. per day in drinking water, the third one received 30 mg/kg Pb2+ kg b.wt. per day in drinking water. Young rats (offspring) were divided into the same respective three groups. Lead, calcium and magnesium content in hard tissues (mandible, femur, teeth-incisors and skull) was determined by flame atomic absorption spectrophotometry in mineralized samples. There was a statistically significant Pb deposition in all analyzed female and young rat hard tissues. Ca and Mg contents were significantly reduced in all female and young rat hard tissues. These results show that Pb poisoning causes a significant reduction in Ca and Mg content in animal hard tissues, which is probably the consequence of competitive antagonism between Pb and Ca and Mg.en
dc.publisherJohn Libbey Eurotext Ltd, Montrouge
dc.rightsrestrictedAccess
dc.sourceMagnesium Research
dc.subjectleaden
dc.subjectmagnesiumen
dc.subjectcalciumen
dc.subjecthard tissuesen
dc.titleCalcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxicationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДозић, Иван; Тодоровић, Татјана; Вујановић, Драгана; Петковић-Ћурчин, Aлександра;
dc.citation.volume21
dc.citation.issue1
dc.citation.spage43
dc.citation.epage50
dc.citation.other21(1): 43-50
dc.citation.rankM23
dc.identifier.wos000255166500005
dc.identifier.pmid18557133
dc.identifier.scopus2-s2.0-42549142194
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_farfar_1087
dc.type.versionpublishedVersion


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