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dc.creatorParojčić, Jelena
dc.creatorVasiljević, Dragana
dc.creatorIbrić, Svetlana
dc.creatorĐurić, Zorica
dc.date.accessioned2019-09-02T11:13:53Z
dc.date.available2019-09-02T11:13:53Z
dc.date.issued2008
dc.identifier.issn0378-5173
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1088
dc.description.abstractAn investigation into the influence of viscous media on tablet disintegration and drug dissolution was performed with the aim to simulate the potential formulation-specific food effect for a selected highly soluble model drug. Literature data on the in vivo drug absorption in fasted and fed state have been evaluated for in vitro-in vivo correlation (IVIVC) purposes. In vitro studies were conducted in simple buffer media with or without addition of HPMC K4M as a viscosity enhancing agent. Good IVIVC correlation (r > 0.95) was obtained for paracetamol dissolution in viscous media at 50 rpm and fed state absorption profiles, while in vitro dissolution in simple media at lower stirring speed was predictable of drug products in vivo behaviour in the fasted state. The data obtained support the existing idea that relatively simple dissolution media and/or set of experimental conditions may be used to differentiate formulation-specific food-drug interactions. Such tests would be a useful tool in the development of formulations that would not be susceptible to the influence of co-administered meal and, furthermore, facilitate regulatory decision on the necessity to conduct food effect studies in vivo.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Pharmaceutics
dc.subjectfood effecten
dc.subjectin vitro-in vivo correlationen
dc.subjectparacetamolen
dc.subjectviscous mediaen
dc.titleTablet disintegration and drug dissolution in viscous media: Paracetamol IR tabletsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВасиљевић, Драгана; Паројчић, Јелена; Ђурић, Зорица; Ибрић, Светлана;
dc.citation.volume355
dc.citation.issue1-2
dc.citation.spage93
dc.citation.epage99
dc.citation.other355(1-2): 93-99
dc.citation.rankM22
dc.identifier.wos000255696200011
dc.identifier.doi10.1016/j.ijpharm.2007.11.058
dc.identifier.pmid18226480
dc.identifier.scopus2-s2.0-41449099515
dc.identifier.rcubconv_1991
dc.type.versionpublishedVersion


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