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dc.creatorPfendt, Lidija
dc.creatorPopović, Gordana
dc.date.accessioned2019-09-02T10:48:41Z
dc.date.available2019-09-02T10:48:41Z
dc.date.issued1994
dc.identifier.issn1472-779X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/108
dc.description.abstractA general spectrophotometric method is proposed for the quantitative investigation of the hydrolysis of 1,4-benzodiazepines which, under the effect of nucleophilic hydration, undergo reversible cleavage of the 4,5-azomethine bond, followed by simultaneous simple acid-base reactions. The method is based on establishing the pH region of the solution in which, at the state of complete equilibration, three species dominate, as well as on using suitable isosbestic points and the differences in rates of simple protolysis and hydrolysis. The method is presented using flurazepam as an example, but it also can be applied to other compounds which hydrolyse by a similar mechanism.en
dc.rightsrestrictedAccess
dc.sourceJournal of the Chemical Society, Perkin Transactions 2
dc.titleA spectrophotometric method for the determination of equilibrium constants of the reversible 1,4-benzodiazepine ring-opening reactionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПфендт, Лидија; Поповић, Гордана;
dc.citation.issue8
dc.citation.spage1845
dc.citation.epage1848
dc.citation.other(8): 1845-1848
dc.identifier.scopus2-s2.0-37049073858
dc.identifier.rcubconv_5464
dc.type.versionpublishedVersion


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