Приказ основних података о документу

dc.creatorČudina, Olivera
dc.creatorBrborić, Jasmina
dc.creatorJanković, I.
dc.creatorKarljiković-Rajić, Katarina
dc.creatorVladimirova, S.
dc.date.accessioned2019-09-02T11:13:55Z
dc.date.available2019-09-02T11:13:55Z
dc.date.issued2008
dc.identifier.issn0927-7765
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1090
dc.description.abstractIn this study, the interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on spectroscopic and acid-base properties of VAL was carried out using UV spectrophotometry at physiological conditions (pH 7.4). The binding of VAL to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.69) proving the great affinity of VAL dianion for the positively charged CTAB micelle surface. To quantify the degree of VAL/CTAB interaction, two constants were calculated by using mathematical models: micelle/water partition coefficient (K-x) and drug/micelle binding constant (K-b). The decrease of K-x with VAL concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 295 nm on CTAB concentration, by using mathematical model that treats the solubilization of VAL dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant (K-b = (2.50 +/- 10.49) x 10(4) M-1) was obtained. Binding constant VAL/CTAB was also calculated using micellar liquid chromatography (MLC).en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142072/RS//
dc.rightsrestrictedAccess
dc.sourceColloids and Surfaces B: Biointerfaces
dc.subjectvalsartanen
dc.subjectmicellesen
dc.subjectCTABen
dc.subjectbinding constanten
dc.subjectpartition coefficienten
dc.titleStudy of valsartan interaction with micelles as a model system for biomembranesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЧудина, Оливера; Карљиковић-Рајић, Катарина; Брборић, Јасмина; Јанковић, И.; Владимирова, С.;
dc.citation.volume65
dc.citation.issue1
dc.citation.spage80
dc.citation.epage84
dc.citation.other65(1): 80-84
dc.citation.rankM22
dc.identifier.wos000257618200013
dc.identifier.doi10.1016/j.colsurfb.2008.03.002
dc.identifier.pmid18439806
dc.identifier.scopus2-s2.0-44649165054
dc.type.versionpublishedVersion


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Приказ основних података о документу