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dc.creatorStepanović-Petrović, Radica
dc.creatorTomić, Maja
dc.creatorVučković, Sonja M.
dc.creatorKocev, Nikola
dc.creatorUgrešić, Nenad
dc.creatorProstran, Milica
dc.creatorBošković, Bogdan
dc.date.accessioned2019-09-02T11:13:56Z
dc.date.available2019-09-02T11:13:56Z
dc.date.issued2008
dc.identifier.issn0031-7012
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1092
dc.description.abstractBackground/Aims: The purpose of this study was to investigate the involvement of GABAergic mechanisms in the antihyperalgesic effect of carbamazepine and oxcarbazepine by examining the effect of bicuculline ( GABA A receptor antagonist) on these effects of antiepileptic drugs. Methods: Rats were intraplantarly (i.pl.) injected with the proinflammatory compound concanavalin A ( Con A). A paw-pressure test was used to determine: ( 1) the development of hyperalgesia induced by Con A; ( 2) the effects of carbamazepine/ oxcarbazepine on Con A-induced hyperalgesia, and ( 3) the effects of bicuculline on the carbamazepine/ oxcarbazepine antihyperalgesia. Results: Intraperitoneally injected bicuculline (0.5 - 1 mg/kg, i.p.) exhibited significant suppression of the systemic antihyperalgesic effects of carbamazepine ( 27 mg/ kg, i.p.) and oxcarbazepine ( 80 mg/ kg, i.p.). When applied intraplantarly, bicuculline ( 0.14 mg/ paw, i.pl.) did not produce any change in the peripheral antihyperalgesic effects of carbamazepine ( 0.14 mg/ paw, i.pl.) and oxcarbazepine (0.5 mg/paw, i.pl.). Bicuculline alone did not produce an intrinsic effect in the paw-pressure test. Conclusion: These results indicate that the antihyperalgesic effects of carbamazepine and oxcarbazepine against inflammatory hyperalgesia involve in part the GABAergic inhibitory modulation of pain transmission at central, but not at peripheral sites, which is mediated via GABA A receptor activation. Copyrighten
dc.publisherKarger, Basel
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145001/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145030/RS//
dc.rightsrestrictedAccess
dc.sourcePharmacology
dc.subjectcarbamazepineen
dc.subjectxcarbazepineen
dc.subjectbicucullineen
dc.subjectpaw-pressure testen
dc.subjectinflammatory hyperalgesiaen
dc.titleGABAergic mechanisms are involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory hyperalgesiaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПростран, Милица; Угрешић, Ненад; Томић, Маја; Степановић-Петровић, Радица; Бошковић, Богдан; Вучковић, Соња М.; Коцев, Никола;
dc.citation.volume82
dc.citation.issue1
dc.citation.spage53
dc.citation.epage58
dc.citation.other82(1): 53-58
dc.citation.rankM22
dc.identifier.wos000256752100008
dc.identifier.doi10.1159/000127841
dc.identifier.pmid18434764
dc.identifier.scopus2-s2.0-46449128393
dc.identifier.rcubconv_2005
dc.type.versionpublishedVersion


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