Catecholamines as immunomodulators: A role for adrenoceptor-mediated mechanisms in fine tuning of T-cell development
Само за регистроване кориснике
2008
Аутори
Leposavić, GordanaPilipović, Ivan
Radojević, Katarina
Pešić, Vesna
Perišić, Milica
Kosec, Duško
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In its simplest form, effective T cell-mediated immunity emanates from the expansion of specific T cells activated tit response to antigen. In establishing and maintaining the peripheral T-cell pool, the thymus plays a critical role. It does so by providing a microenvironment within which T cell precursors proliferate, differentiate and Undergo selection processes to create a fully functional population of major histocompatibility complex restricted, self-tolerant T cells. The control of the thymic function involves intrathymic, as well as sympathetic nervous and endocrine system signalling. In addition to postganglionic noradrenergic fibres, both thymic lymphoid and non-lymphoid cells, including epithelial cells and macrophages. have been demo nstrated to express tyrosine hydroxylase (TH), and Suggested to form a local non-neural catecholaminergic cell network. A higher level of noradrenaline has been found in male than in female rat thymi. and a role of,gonadal hormones ill providing... this dimorphism has been demonstrated. In addition, thymic lymphoid and non-lymphoid cells, including those expressing TH, have been found to bear beta- and alpha(1)-adrenoceptors (ARs) and a role of gonadal hormones in regulation of, at least. beta-AR density and signalling has been Suggested. These findings have also entailed conclusion that catecholamiens (CAs) influence T-cell development, not only via neurocrine/endocrine, but also via autocrine/paracrine action. Generally, CAs have been shown to exert an inhibitory influence on thymopoiesis. Role of alpha(1)- and beta-R-mediated mechanisms in maintaining thymic homeostasis and in fine tuning of both conventional and regulatory T-cell development is discussed in the Manuscript.
Кључне речи:
Tyrosine hydroxylase immunoreactivity / Sympathetic innervation / beta-adrenoceptors / alpha 1-adrenoceptors / ThymopoiesisИзвор:
Autonomic Neuroscience-Basic & Clinical, 2008, 144, 1-2, 1-12Издавач:
- Elsevier Science BV, Amsterdam
Финансирање / пројекти:
DOI: 10.1016/j.autneu.2008.09.003
ISSN: 1566-0702
PubMed: 18976969
WoS: 000261857300001
Scopus: 2-s2.0-56349095878
Институција/група
PharmacyTY - JOUR AU - Leposavić, Gordana AU - Pilipović, Ivan AU - Radojević, Katarina AU - Pešić, Vesna AU - Perišić, Milica AU - Kosec, Duško PY - 2008 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1094 AB - In its simplest form, effective T cell-mediated immunity emanates from the expansion of specific T cells activated tit response to antigen. In establishing and maintaining the peripheral T-cell pool, the thymus plays a critical role. It does so by providing a microenvironment within which T cell precursors proliferate, differentiate and Undergo selection processes to create a fully functional population of major histocompatibility complex restricted, self-tolerant T cells. The control of the thymic function involves intrathymic, as well as sympathetic nervous and endocrine system signalling. In addition to postganglionic noradrenergic fibres, both thymic lymphoid and non-lymphoid cells, including epithelial cells and macrophages. have been demo nstrated to express tyrosine hydroxylase (TH), and Suggested to form a local non-neural catecholaminergic cell network. A higher level of noradrenaline has been found in male than in female rat thymi. and a role of,gonadal hormones ill providing this dimorphism has been demonstrated. In addition, thymic lymphoid and non-lymphoid cells, including those expressing TH, have been found to bear beta- and alpha(1)-adrenoceptors (ARs) and a role of gonadal hormones in regulation of, at least. beta-AR density and signalling has been Suggested. These findings have also entailed conclusion that catecholamiens (CAs) influence T-cell development, not only via neurocrine/endocrine, but also via autocrine/paracrine action. Generally, CAs have been shown to exert an inhibitory influence on thymopoiesis. Role of alpha(1)- and beta-R-mediated mechanisms in maintaining thymic homeostasis and in fine tuning of both conventional and regulatory T-cell development is discussed in the Manuscript. PB - Elsevier Science BV, Amsterdam T2 - Autonomic Neuroscience-Basic & Clinical T1 - Catecholamines as immunomodulators: A role for adrenoceptor-mediated mechanisms in fine tuning of T-cell development VL - 144 IS - 1-2 SP - 1 EP - 12 DO - 10.1016/j.autneu.2008.09.003 ER -
@article{ author = "Leposavić, Gordana and Pilipović, Ivan and Radojević, Katarina and Pešić, Vesna and Perišić, Milica and Kosec, Duško", year = "2008", abstract = "In its simplest form, effective T cell-mediated immunity emanates from the expansion of specific T cells activated tit response to antigen. In establishing and maintaining the peripheral T-cell pool, the thymus plays a critical role. It does so by providing a microenvironment within which T cell precursors proliferate, differentiate and Undergo selection processes to create a fully functional population of major histocompatibility complex restricted, self-tolerant T cells. The control of the thymic function involves intrathymic, as well as sympathetic nervous and endocrine system signalling. In addition to postganglionic noradrenergic fibres, both thymic lymphoid and non-lymphoid cells, including epithelial cells and macrophages. have been demo nstrated to express tyrosine hydroxylase (TH), and Suggested to form a local non-neural catecholaminergic cell network. A higher level of noradrenaline has been found in male than in female rat thymi. and a role of,gonadal hormones ill providing this dimorphism has been demonstrated. In addition, thymic lymphoid and non-lymphoid cells, including those expressing TH, have been found to bear beta- and alpha(1)-adrenoceptors (ARs) and a role of gonadal hormones in regulation of, at least. beta-AR density and signalling has been Suggested. These findings have also entailed conclusion that catecholamiens (CAs) influence T-cell development, not only via neurocrine/endocrine, but also via autocrine/paracrine action. Generally, CAs have been shown to exert an inhibitory influence on thymopoiesis. Role of alpha(1)- and beta-R-mediated mechanisms in maintaining thymic homeostasis and in fine tuning of both conventional and regulatory T-cell development is discussed in the Manuscript.", publisher = "Elsevier Science BV, Amsterdam", journal = "Autonomic Neuroscience-Basic & Clinical", title = "Catecholamines as immunomodulators: A role for adrenoceptor-mediated mechanisms in fine tuning of T-cell development", volume = "144", number = "1-2", pages = "1-12", doi = "10.1016/j.autneu.2008.09.003" }
Leposavić, G., Pilipović, I., Radojević, K., Pešić, V., Perišić, M.,& Kosec, D.. (2008). Catecholamines as immunomodulators: A role for adrenoceptor-mediated mechanisms in fine tuning of T-cell development. in Autonomic Neuroscience-Basic & Clinical Elsevier Science BV, Amsterdam., 144(1-2), 1-12. https://doi.org/10.1016/j.autneu.2008.09.003
Leposavić G, Pilipović I, Radojević K, Pešić V, Perišić M, Kosec D. Catecholamines as immunomodulators: A role for adrenoceptor-mediated mechanisms in fine tuning of T-cell development. in Autonomic Neuroscience-Basic & Clinical. 2008;144(1-2):1-12. doi:10.1016/j.autneu.2008.09.003 .
Leposavić, Gordana, Pilipović, Ivan, Radojević, Katarina, Pešić, Vesna, Perišić, Milica, Kosec, Duško, "Catecholamines as immunomodulators: A role for adrenoceptor-mediated mechanisms in fine tuning of T-cell development" in Autonomic Neuroscience-Basic & Clinical, 144, no. 1-2 (2008):1-12, https://doi.org/10.1016/j.autneu.2008.09.003 . .