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The values of estimated glomerular filtration rate calculated with creatinine and cystatin C based equations in healthy adults

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Authors
Dajak, Marijana
Ignjatović, Svetlana
Jovičić, Snežana
Majkić-Singh, Nada
Article (Published version)
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Abstract
The glomerullar filtration rate (GFR) is widely accepted as the best overall index of kidney function. GFR can be measured as the clearance of exogenous or endogenous filtration markers or clinically estimated from serum concentrations or creatinine or cystatin C. Recently, it has been recommended that an estimated GFR (eGFR) should be reported in addition to the value of filtration markers. In this study, we determined the values of eGFR, based on creatinine and cystatin C equations, in 125 healthy volunteers aged 20-75 years. Creatinine was measured by a kinetic alkaline picrate method on an ARCHITECT ci8200 analyzer (Abbott Diagnostics, Wiesbaden, Germany). Cystatin C was determined by a latex particle-enhanced immunonephelometric assay (BNII, Dade Behring, Marburg, Germany). The eGFR values were calculated for creatinine using the Modification of Diet in Renal Disease (MDRD) study equation and Rule's quadratic equation and for cystatin C according to the equation published by Hoek ...et al. The reference intervals for eGFRs with MDRD, Rule's quadratic and Hoek's equations were calculated nonparametrically and were determined to be 63.5-124.6 mL/min/1.73 m(2), 78.3-139.2 mL/min/1.73 m(2) and 72.2-115.6 mL/min/1.73 m(2), respectively. According to the US National Kidney Foundation, chronic kidney disease (CKD) can be defined as a GFR lt 60 mL/min/1.73 m(2). Our results showed that healthy adults had eGFR values > 63.5 mL/min/1.73 m(2). However, it is important to note that these normal values overlap with values in stages 1 and 2 of CKD, thus an eGFR greater than 60 mL/min/1.73 m(2) does not exclude kidney disease.

Keywords:
estimated glomerular filtration rate / creatinine / cystatin C / prediction equations / reference values
Source:
Clinical Laboratory, 2008, 54, 5-6, 153-159
Publisher:
  • Clin Lab Publ, Heidelberg
Funding / projects:
  • Biohemijski pokazatelji oštećenja i disfunkcije organa (RS-145010)

ISSN: 1433-6510

PubMed: 18780660

WoS: 000259004700002

[ Google Scholar ]
5
Handle
https://hdl.handle.net/21.15107/rcub_farfar_1097
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1097
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Dajak, Marijana
AU  - Ignjatović, Svetlana
AU  - Jovičić, Snežana
AU  - Majkić-Singh, Nada
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1097
AB  - The glomerullar filtration rate (GFR) is widely accepted as the best overall index of kidney function. GFR can be measured as the clearance of exogenous or endogenous filtration markers or clinically estimated from serum concentrations or creatinine or cystatin C. Recently, it has been recommended that an estimated GFR (eGFR) should be reported in addition to the value of filtration markers. In this study, we determined the values of eGFR, based on creatinine and cystatin C equations, in 125 healthy volunteers aged 20-75 years. Creatinine was measured by a kinetic alkaline picrate method on an ARCHITECT ci8200 analyzer (Abbott Diagnostics, Wiesbaden, Germany). Cystatin C was determined by a latex particle-enhanced immunonephelometric assay (BNII, Dade Behring, Marburg, Germany). The eGFR values were calculated for creatinine using the Modification of Diet in Renal Disease (MDRD) study equation and Rule's quadratic equation and for cystatin C according to the equation published by Hoek et al. The reference intervals for eGFRs with MDRD, Rule's quadratic and Hoek's equations were calculated nonparametrically and were determined to be 63.5-124.6 mL/min/1.73 m(2), 78.3-139.2 mL/min/1.73 m(2) and 72.2-115.6 mL/min/1.73 m(2), respectively. According to the US National Kidney Foundation, chronic kidney disease (CKD) can be defined as a GFR  lt  60 mL/min/1.73 m(2). Our results showed that healthy adults had eGFR values > 63.5 mL/min/1.73 m(2). However, it is important to note that these normal values overlap with values in stages 1 and 2 of CKD, thus an eGFR greater than 60 mL/min/1.73 m(2) does not exclude kidney disease.
PB  - Clin Lab Publ, Heidelberg
T2  - Clinical Laboratory
T1  - The values of estimated glomerular filtration rate calculated with creatinine and cystatin C based equations in healthy adults
VL  - 54
IS  - 5-6
SP  - 153
EP  - 159
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1097
ER  - 
@article{
author = "Dajak, Marijana and Ignjatović, Svetlana and Jovičić, Snežana and Majkić-Singh, Nada",
year = "2008",
abstract = "The glomerullar filtration rate (GFR) is widely accepted as the best overall index of kidney function. GFR can be measured as the clearance of exogenous or endogenous filtration markers or clinically estimated from serum concentrations or creatinine or cystatin C. Recently, it has been recommended that an estimated GFR (eGFR) should be reported in addition to the value of filtration markers. In this study, we determined the values of eGFR, based on creatinine and cystatin C equations, in 125 healthy volunteers aged 20-75 years. Creatinine was measured by a kinetic alkaline picrate method on an ARCHITECT ci8200 analyzer (Abbott Diagnostics, Wiesbaden, Germany). Cystatin C was determined by a latex particle-enhanced immunonephelometric assay (BNII, Dade Behring, Marburg, Germany). The eGFR values were calculated for creatinine using the Modification of Diet in Renal Disease (MDRD) study equation and Rule's quadratic equation and for cystatin C according to the equation published by Hoek et al. The reference intervals for eGFRs with MDRD, Rule's quadratic and Hoek's equations were calculated nonparametrically and were determined to be 63.5-124.6 mL/min/1.73 m(2), 78.3-139.2 mL/min/1.73 m(2) and 72.2-115.6 mL/min/1.73 m(2), respectively. According to the US National Kidney Foundation, chronic kidney disease (CKD) can be defined as a GFR  lt  60 mL/min/1.73 m(2). Our results showed that healthy adults had eGFR values > 63.5 mL/min/1.73 m(2). However, it is important to note that these normal values overlap with values in stages 1 and 2 of CKD, thus an eGFR greater than 60 mL/min/1.73 m(2) does not exclude kidney disease.",
publisher = "Clin Lab Publ, Heidelberg",
journal = "Clinical Laboratory",
title = "The values of estimated glomerular filtration rate calculated with creatinine and cystatin C based equations in healthy adults",
volume = "54",
number = "5-6",
pages = "153-159",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1097"
}
Dajak, M., Ignjatović, S., Jovičić, S.,& Majkić-Singh, N.. (2008). The values of estimated glomerular filtration rate calculated with creatinine and cystatin C based equations in healthy adults. in Clinical Laboratory
Clin Lab Publ, Heidelberg., 54(5-6), 153-159.
https://hdl.handle.net/21.15107/rcub_farfar_1097
Dajak M, Ignjatović S, Jovičić S, Majkić-Singh N. The values of estimated glomerular filtration rate calculated with creatinine and cystatin C based equations in healthy adults. in Clinical Laboratory. 2008;54(5-6):153-159.
https://hdl.handle.net/21.15107/rcub_farfar_1097 .
Dajak, Marijana, Ignjatović, Svetlana, Jovičić, Snežana, Majkić-Singh, Nada, "The values of estimated glomerular filtration rate calculated with creatinine and cystatin C based equations in healthy adults" in Clinical Laboratory, 54, no. 5-6 (2008):153-159,
https://hdl.handle.net/21.15107/rcub_farfar_1097 .

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