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dc.creatorDajak, Marijana
dc.creatorIgnjatović, Svetlana
dc.creatorJovičić, Snežana
dc.creatorMajkić-Singh, Nada
dc.date.accessioned2019-09-02T11:14:05Z
dc.date.available2019-09-02T11:14:05Z
dc.date.issued2008
dc.identifier.issn1433-6510
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1097
dc.description.abstractThe glomerullar filtration rate (GFR) is widely accepted as the best overall index of kidney function. GFR can be measured as the clearance of exogenous or endogenous filtration markers or clinically estimated from serum concentrations or creatinine or cystatin C. Recently, it has been recommended that an estimated GFR (eGFR) should be reported in addition to the value of filtration markers. In this study, we determined the values of eGFR, based on creatinine and cystatin C equations, in 125 healthy volunteers aged 20-75 years. Creatinine was measured by a kinetic alkaline picrate method on an ARCHITECT ci8200 analyzer (Abbott Diagnostics, Wiesbaden, Germany). Cystatin C was determined by a latex particle-enhanced immunonephelometric assay (BNII, Dade Behring, Marburg, Germany). The eGFR values were calculated for creatinine using the Modification of Diet in Renal Disease (MDRD) study equation and Rule's quadratic equation and for cystatin C according to the equation published by Hoek et al. The reference intervals for eGFRs with MDRD, Rule's quadratic and Hoek's equations were calculated nonparametrically and were determined to be 63.5-124.6 mL/min/1.73 m(2), 78.3-139.2 mL/min/1.73 m(2) and 72.2-115.6 mL/min/1.73 m(2), respectively. According to the US National Kidney Foundation, chronic kidney disease (CKD) can be defined as a GFR lt 60 mL/min/1.73 m(2). Our results showed that healthy adults had eGFR values > 63.5 mL/min/1.73 m(2). However, it is important to note that these normal values overlap with values in stages 1 and 2 of CKD, thus an eGFR greater than 60 mL/min/1.73 m(2) does not exclude kidney disease.en
dc.publisherClin Lab Publ, Heidelberg
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145010/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Laboratory
dc.subjectestimated glomerular filtration rateen
dc.subjectcreatinineen
dc.subjectcystatin Cen
dc.subjectprediction equationsen
dc.subjectreference valuesen
dc.titleThe values of estimated glomerular filtration rate calculated with creatinine and cystatin C based equations in healthy adultsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМајкић-Сингх, Нада; Дајак, Маријана; Игњатовић, Светлана; Јовичић, Снежана;
dc.citation.volume54
dc.citation.issue5-6
dc.citation.spage153
dc.citation.epage159
dc.citation.other54(5-6): 153-159
dc.citation.rankM23
dc.identifier.wos000259004700002
dc.identifier.pmid18780660
dc.identifier.rcubconv_2057
dc.type.versionpublishedVersion


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