The objective of this study was to examine the influence of oral supplementation with Zn or Mg on Cd content in the blood and organs of rabbits exposed to prolonged Cd intoxication. Rabbits were divided into the following groups: Cd group-received orally every day for 4 weeks 10 mg Cd/kg body weight (b.w.), Cd+Zn group and Cd+Mg group-exposed to Cd and supplemented with 20 mg Zn/kg b.w. or 40 mg Mg/kg b.w. 1 h after Cd treatment. Cd content in biological material was determined by atomic absorption spectrophotometry. Blood Cd concentration was determined in all investigated groups at time 0 and after 10, 14, 18, 22, 25, and 28 days, whereas Cd content in the brain, heart, lungs, liver, kidney, spleen, pancreas, skeletal muscle, and bone was determined after 28 days. Blood Cd concentration was significantly increased in all groups from the 14th day of Cd intoxication and lasted till the end of the experiment. Zn or Mg supplementation significantly reduced blood Cd content on the 18th an...d 25th days. Supplementation with Zn or Mg significantly decreased Cd concentration in the kidney, spleen, and bone and, in addition, Zn reduced Cd content in the brain. Supplementation with Zn or Mg in Cd-intoxicated rabbits caused similar reduction of blood Cd concentration; however, reduction of tissue Cd content was more pronounced in Zn- than in Mg-supplemented group.
TY - JOUR
AU - Bulat, Zorica
AU - Đukić-Ćosić, Danijela
AU - Maličević, Živorad
AU - Bulat, Petar
AU - Matović, Vesna
PY - 2008
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1104
AB - The objective of this study was to examine the influence of oral supplementation with Zn or Mg on Cd content in the blood and organs of rabbits exposed to prolonged Cd intoxication. Rabbits were divided into the following groups: Cd group-received orally every day for 4 weeks 10 mg Cd/kg body weight (b.w.), Cd+Zn group and Cd+Mg group-exposed to Cd and supplemented with 20 mg Zn/kg b.w. or 40 mg Mg/kg b.w. 1 h after Cd treatment. Cd content in biological material was determined by atomic absorption spectrophotometry. Blood Cd concentration was determined in all investigated groups at time 0 and after 10, 14, 18, 22, 25, and 28 days, whereas Cd content in the brain, heart, lungs, liver, kidney, spleen, pancreas, skeletal muscle, and bone was determined after 28 days. Blood Cd concentration was significantly increased in all groups from the 14th day of Cd intoxication and lasted till the end of the experiment. Zn or Mg supplementation significantly reduced blood Cd content on the 18th and 25th days. Supplementation with Zn or Mg significantly decreased Cd concentration in the kidney, spleen, and bone and, in addition, Zn reduced Cd content in the brain. Supplementation with Zn or Mg in Cd-intoxicated rabbits caused similar reduction of blood Cd concentration; however, reduction of tissue Cd content was more pronounced in Zn- than in Mg-supplemented group.
PB - Humana Press Inc, Totowa
T2 - Biological Trace Element Research
T1 - Zinc or magnesium supplementation modulates Cd intoxication in blood, kidney, spleen, and bone of rabbits
VL - 124
IS - 2
SP - 110
EP - 117
DO - 10.1007/s12011-008-8128-5
ER -
@article{
author = "Bulat, Zorica and Đukić-Ćosić, Danijela and Maličević, Živorad and Bulat, Petar and Matović, Vesna",
year = "2008",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/1104",
abstract = "The objective of this study was to examine the influence of oral supplementation with Zn or Mg on Cd content in the blood and organs of rabbits exposed to prolonged Cd intoxication. Rabbits were divided into the following groups: Cd group-received orally every day for 4 weeks 10 mg Cd/kg body weight (b.w.), Cd+Zn group and Cd+Mg group-exposed to Cd and supplemented with 20 mg Zn/kg b.w. or 40 mg Mg/kg b.w. 1 h after Cd treatment. Cd content in biological material was determined by atomic absorption spectrophotometry. Blood Cd concentration was determined in all investigated groups at time 0 and after 10, 14, 18, 22, 25, and 28 days, whereas Cd content in the brain, heart, lungs, liver, kidney, spleen, pancreas, skeletal muscle, and bone was determined after 28 days. Blood Cd concentration was significantly increased in all groups from the 14th day of Cd intoxication and lasted till the end of the experiment. Zn or Mg supplementation significantly reduced blood Cd content on the 18th and 25th days. Supplementation with Zn or Mg significantly decreased Cd concentration in the kidney, spleen, and bone and, in addition, Zn reduced Cd content in the brain. Supplementation with Zn or Mg in Cd-intoxicated rabbits caused similar reduction of blood Cd concentration; however, reduction of tissue Cd content was more pronounced in Zn- than in Mg-supplemented group.",
publisher = "Humana Press Inc, Totowa",
journal = "Biological Trace Element Research",
title = "Zinc or magnesium supplementation modulates Cd intoxication in blood, kidney, spleen, and bone of rabbits",
volume = "124",
number = "2",
pages = "110-117",
doi = "10.1007/s12011-008-8128-5"
}
Bulat, Z., Đukić-Ćosić, D., Maličević, Ž., Bulat, P.,& Matović, V. (2008). Zinc or magnesium supplementation modulates Cd intoxication in blood, kidney, spleen, and bone of rabbits.
Biological Trace Element Research
Humana Press Inc, Totowa., 124(2), 110-117.
https://doi.org/10.1007/s12011-008-8128-5
Bulat Z, Đukić-Ćosić D, Maličević Ž, Bulat P, Matović V. Zinc or magnesium supplementation modulates Cd intoxication in blood, kidney, spleen, and bone of rabbits. Biological Trace Element Research. 2008;124(2):110-117
Bulat Zorica, Đukić-Ćosić Danijela, Maličević Živorad, Bulat Petar, Matović Vesna, "Zinc or magnesium supplementation modulates Cd intoxication in blood, kidney, spleen, and bone of rabbits" Biological Trace Element Research, 124, no. 2 (2008):110-117,
https://doi.org/10.1007/s12011-008-8128-5 .
