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Beneficial effects of dimethyl fumarate on experimental autoimmune myocarditis

rcub.bitstream.locked
2008
Authors
Milenković, Marina
Arsenović-Ranin, Nevena
Božić, Dragana
Bufan, Biljana
Jančić, Ivan
Stojić-Vukanić, Zorica
Article (Published version)
Metadata
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Abstract
Background. Fumaric acid esters (FAE) have been proven to be effective for the systemic treatment of psoriasis and multiple sclerosis, Thl cell-mediated chronic inflammatory diseases, but their effect on autoimmune rnyocarditis has not yet been addressed. We investigated the effect of dimethyl fumarate (DMF) on myosin-induced experimental autoimmune myocarditis (EAM). Methods. Dark Agouti (DA) rats immunized with porcine cardiac myosin were orally treated with 5 and 15 mg/kg body weight (bw) DMF either from days 0-10 (early treatment groups) or from days 10-21 (late treatment groups) after induction of EAM. All rats were sacrificed on day 21 after immunization and hearts were evaluated macroscopically and microscopically. Levels of TNF-alpha and IL-10 in serum and lymph node cells culture supernatants were detected by ELISA. Results. Both early and late treatment with 15 mg/kg body weight (bw) DMF markedly C, reduced the severity of myocarditis by comparing the incidence, heart weight ...bw ratio, macroscopic and microscopic scores, and number of OX-6+ cells in the myocardium. Further, levels of tumor necrosis factor-alpha (TNF-alpha) in serum and culture supernatants of lymph node cells stimulated with ConA or myosin were significantly lower in DNIF-treated EAM animals compared with vehicle-treated EAM rats. There was no significant difference in serum levels of interleukin-10 between DMF- and vehicle-treated EAM rats. Conclusions. These results show for the first time that DMF ameliorates experimental autoimmune rnyocarditis and may be acted, at least in part, by interfering with the production of TNF-alpha.

Keywords:
rats / experimental autoimmune myocarditis / dimethyl fumarate / tumor necrosis factor-alpha / interleukin-10
Source:
Archives of Medical Research, 2008, 39, 7, 639-646
Publisher:
  • Elsevier Science Inc, New York

DOI: 10.1016/j.arcmed.2008.07.003

ISSN: 0188-4409

PubMed: 18760191

WoS: 000259418800002

Scopus: 2-s2.0-50049108903
[ Google Scholar ]
15
14
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1107
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Milenković, Marina
AU  - Arsenović-Ranin, Nevena
AU  - Božić, Dragana
AU  - Bufan, Biljana
AU  - Jančić, Ivan
AU  - Stojić-Vukanić, Zorica
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1107
AB  - Background. Fumaric acid esters (FAE) have been proven to be effective for the systemic treatment of psoriasis and multiple sclerosis, Thl cell-mediated chronic inflammatory diseases, but their effect on autoimmune rnyocarditis has not yet been addressed. We investigated the effect of dimethyl fumarate (DMF) on myosin-induced experimental autoimmune myocarditis (EAM). Methods. Dark Agouti (DA) rats immunized with porcine cardiac myosin were orally treated with 5 and 15 mg/kg body weight (bw) DMF either from days 0-10 (early treatment groups) or from days 10-21 (late treatment groups) after induction of EAM. All rats were sacrificed on day 21 after immunization and hearts were evaluated macroscopically and microscopically. Levels of TNF-alpha and IL-10 in serum and lymph node cells culture supernatants were detected by ELISA. Results. Both early and late treatment with 15 mg/kg body weight (bw) DMF markedly C, reduced the severity of myocarditis by comparing the incidence, heart weight bw ratio, macroscopic and microscopic scores, and number of OX-6+ cells in the myocardium. Further, levels of tumor necrosis factor-alpha (TNF-alpha) in serum and culture supernatants of lymph node cells stimulated with ConA or myosin were significantly lower in DNIF-treated EAM animals compared with vehicle-treated EAM rats. There was no significant difference in serum levels of interleukin-10 between DMF- and vehicle-treated EAM rats. Conclusions. These results show for the first time that DMF ameliorates experimental autoimmune rnyocarditis and may be acted, at least in part, by interfering with the production of TNF-alpha.
PB  - Elsevier Science Inc, New York
T2  - Archives of Medical Research
T1  - Beneficial effects of dimethyl fumarate on experimental autoimmune myocarditis
VL  - 39
IS  - 7
SP  - 639
EP  - 646
DO  - 10.1016/j.arcmed.2008.07.003
ER  - 
@article{
author = "Milenković, Marina and Arsenović-Ranin, Nevena and Božić, Dragana and Bufan, Biljana and Jančić, Ivan and Stojić-Vukanić, Zorica",
year = "2008",
abstract = "Background. Fumaric acid esters (FAE) have been proven to be effective for the systemic treatment of psoriasis and multiple sclerosis, Thl cell-mediated chronic inflammatory diseases, but their effect on autoimmune rnyocarditis has not yet been addressed. We investigated the effect of dimethyl fumarate (DMF) on myosin-induced experimental autoimmune myocarditis (EAM). Methods. Dark Agouti (DA) rats immunized with porcine cardiac myosin were orally treated with 5 and 15 mg/kg body weight (bw) DMF either from days 0-10 (early treatment groups) or from days 10-21 (late treatment groups) after induction of EAM. All rats were sacrificed on day 21 after immunization and hearts were evaluated macroscopically and microscopically. Levels of TNF-alpha and IL-10 in serum and lymph node cells culture supernatants were detected by ELISA. Results. Both early and late treatment with 15 mg/kg body weight (bw) DMF markedly C, reduced the severity of myocarditis by comparing the incidence, heart weight bw ratio, macroscopic and microscopic scores, and number of OX-6+ cells in the myocardium. Further, levels of tumor necrosis factor-alpha (TNF-alpha) in serum and culture supernatants of lymph node cells stimulated with ConA or myosin were significantly lower in DNIF-treated EAM animals compared with vehicle-treated EAM rats. There was no significant difference in serum levels of interleukin-10 between DMF- and vehicle-treated EAM rats. Conclusions. These results show for the first time that DMF ameliorates experimental autoimmune rnyocarditis and may be acted, at least in part, by interfering with the production of TNF-alpha.",
publisher = "Elsevier Science Inc, New York",
journal = "Archives of Medical Research",
title = "Beneficial effects of dimethyl fumarate on experimental autoimmune myocarditis",
volume = "39",
number = "7",
pages = "639-646",
doi = "10.1016/j.arcmed.2008.07.003"
}
Milenković, M., Arsenović-Ranin, N., Božić, D., Bufan, B., Jančić, I.,& Stojić-Vukanić, Z.. (2008). Beneficial effects of dimethyl fumarate on experimental autoimmune myocarditis. in Archives of Medical Research
Elsevier Science Inc, New York., 39(7), 639-646.
https://doi.org/10.1016/j.arcmed.2008.07.003
Milenković M, Arsenović-Ranin N, Božić D, Bufan B, Jančić I, Stojić-Vukanić Z. Beneficial effects of dimethyl fumarate on experimental autoimmune myocarditis. in Archives of Medical Research. 2008;39(7):639-646.
doi:10.1016/j.arcmed.2008.07.003 .
Milenković, Marina, Arsenović-Ranin, Nevena, Božić, Dragana, Bufan, Biljana, Jančić, Ivan, Stojić-Vukanić, Zorica, "Beneficial effects of dimethyl fumarate on experimental autoimmune myocarditis" in Archives of Medical Research, 39, no. 7 (2008):639-646,
https://doi.org/10.1016/j.arcmed.2008.07.003 . .

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