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Optimal conditions for extraction and simultaneous determination of sulfamethoxazole and trimethoprim in pharmaceuticals by micellar electrokinetic capillary chromatography

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Authors
Injac, Rade
Kac, Javor
Karljiković-Rajić, Katarina
Štrukelj, Borut
Article (Published version)
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Abstract
A micellar electrokinetic capillary chromatography was performed at 25 degrees C and 30 kV (under pressure of 15 mbar), with 30 mM berate buffer (pH 9.0), 60 mM sodium dodecysulfate, and 10% (v/v) ethanol as background electrolyte for the determination of sulfamethoxazole and trimethoprim. UV detection was at 205 nm. Recoveries were optimal and acceptable after extraction with ethanol / deionized water (1:1, v/v) for both investigated compounds from laboratory mixtures of standards. The method was shown to be specific, accurate (recoveries were 99.9 +/- 0.4% for sulfamethoxazole and 99.8 +/- 0.3% for trimethoprim), linear over the tested ranges (correlation coefficients >= 0.9990) and precise (RSD below 0.6%). The method was applied to determine sulfamethoxazole and trimethoprim in tablets, powder for cutaneous use and solution for infusion.
Keywords:
sulfamethoxazole / trimethoprim / LLE / micellar electrokinetic capillary chromatography (MEKC) / pharmaceuticals
Source:
Journal of Food and Drug Analysis, 2008, 16, 1, 18-25
Publisher:
  • Food & Drug Adminstration, Taipei

ISSN: 1021-9498

WoS: 000253828800003

Scopus: 2-s2.0-42249089075
[ Google Scholar ]
6
6
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1110
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Injac, Rade
AU  - Kac, Javor
AU  - Karljiković-Rajić, Katarina
AU  - Štrukelj, Borut
PY  - 2008
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1110
AB  - A micellar electrokinetic capillary chromatography was performed at 25 degrees C and 30 kV (under pressure of 15 mbar), with 30 mM berate buffer (pH 9.0), 60 mM sodium dodecysulfate, and 10% (v/v) ethanol as background electrolyte for the determination of sulfamethoxazole and trimethoprim. UV detection was at 205 nm. Recoveries were optimal and acceptable after extraction with ethanol / deionized water (1:1, v/v) for both investigated compounds from laboratory mixtures of standards. The method was shown to be specific, accurate (recoveries were 99.9 +/- 0.4% for sulfamethoxazole and 99.8 +/- 0.3% for trimethoprim), linear over the tested ranges (correlation coefficients >= 0.9990) and precise (RSD below 0.6%). The method was applied to determine sulfamethoxazole and trimethoprim in tablets, powder for cutaneous use and solution for infusion.
PB  - Food & Drug Adminstration, Taipei
T2  - Journal of Food and Drug Analysis
T1  - Optimal conditions for extraction and simultaneous determination of sulfamethoxazole and trimethoprim in pharmaceuticals by micellar electrokinetic capillary chromatography
VL  - 16
IS  - 1
SP  - 18
EP  - 25
ER  - 
@article{
author = "Injac, Rade and Kac, Javor and Karljiković-Rajić, Katarina and Štrukelj, Borut",
year = "2008",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/1110",
abstract = "A micellar electrokinetic capillary chromatography was performed at 25 degrees C and 30 kV (under pressure of 15 mbar), with 30 mM berate buffer (pH 9.0), 60 mM sodium dodecysulfate, and 10% (v/v) ethanol as background electrolyte for the determination of sulfamethoxazole and trimethoprim. UV detection was at 205 nm. Recoveries were optimal and acceptable after extraction with ethanol / deionized water (1:1, v/v) for both investigated compounds from laboratory mixtures of standards. The method was shown to be specific, accurate (recoveries were 99.9 +/- 0.4% for sulfamethoxazole and 99.8 +/- 0.3% for trimethoprim), linear over the tested ranges (correlation coefficients >= 0.9990) and precise (RSD below 0.6%). The method was applied to determine sulfamethoxazole and trimethoprim in tablets, powder for cutaneous use and solution for infusion.",
publisher = "Food & Drug Adminstration, Taipei",
journal = "Journal of Food and Drug Analysis",
title = "Optimal conditions for extraction and simultaneous determination of sulfamethoxazole and trimethoprim in pharmaceuticals by micellar electrokinetic capillary chromatography",
volume = "16",
number = "1",
pages = "18-25"
}
Injac R, Kac J, Karljiković-Rajić K, Štrukelj B. Optimal conditions for extraction and simultaneous determination of sulfamethoxazole and trimethoprim in pharmaceuticals by micellar electrokinetic capillary chromatography. Journal of Food and Drug Analysis. 2008;16(1):18-25
Injac, R., Kac, J., Karljiković-Rajić, K.,& Štrukelj, B. (2008). Optimal conditions for extraction and simultaneous determination of sulfamethoxazole and trimethoprim in pharmaceuticals by micellar electrokinetic capillary chromatography.
Journal of Food and Drug AnalysisFood & Drug Adminstration, Taipei., 16(1), 18-25.
Injac Rade, Kac Javor, Karljiković-Rajić Katarina, Štrukelj Borut, "Optimal conditions for extraction and simultaneous determination of sulfamethoxazole and trimethoprim in pharmaceuticals by micellar electrokinetic capillary chromatography" 16, no. 1 (2008):18-25

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