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Optimal conditions for extraction and simultaneous determination of sulfamethoxazole and trimethoprim in pharmaceuticals by micellar electrokinetic capillary chromatography
dc.creator | Injac, Rade | |
dc.creator | Kac, Javor | |
dc.creator | Karljiković-Rajić, Katarina | |
dc.creator | Štrukelj, Borut | |
dc.date.accessioned | 2019-09-02T11:14:28Z | |
dc.date.available | 2019-09-02T11:14:28Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 1021-9498 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1110 | |
dc.description.abstract | A micellar electrokinetic capillary chromatography was performed at 25 degrees C and 30 kV (under pressure of 15 mbar), with 30 mM berate buffer (pH 9.0), 60 mM sodium dodecysulfate, and 10% (v/v) ethanol as background electrolyte for the determination of sulfamethoxazole and trimethoprim. UV detection was at 205 nm. Recoveries were optimal and acceptable after extraction with ethanol / deionized water (1:1, v/v) for both investigated compounds from laboratory mixtures of standards. The method was shown to be specific, accurate (recoveries were 99.9 +/- 0.4% for sulfamethoxazole and 99.8 +/- 0.3% for trimethoprim), linear over the tested ranges (correlation coefficients >= 0.9990) and precise (RSD below 0.6%). The method was applied to determine sulfamethoxazole and trimethoprim in tablets, powder for cutaneous use and solution for infusion. | en |
dc.publisher | Food & Drug Adminstration, Taipei | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of Food and Drug Analysis | |
dc.subject | sulfamethoxazole | en |
dc.subject | trimethoprim | en |
dc.subject | LLE | en |
dc.subject | micellar electrokinetic capillary chromatography (MEKC) | en |
dc.subject | pharmaceuticals | en |
dc.title | Optimal conditions for extraction and simultaneous determination of sulfamethoxazole and trimethoprim in pharmaceuticals by micellar electrokinetic capillary chromatography | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Штрукељ, Борут; Кац, Јавор; Ињац, Раде; Карљиковић-Рајић, Катарина; | |
dc.citation.volume | 16 | |
dc.citation.issue | 1 | |
dc.citation.spage | 18 | |
dc.citation.epage | 25 | |
dc.citation.other | 16(1): 18-25 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000253828800003 | |
dc.identifier.scopus | 2-s2.0-42249089075 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_1110 | |
dc.type.version | publishedVersion |
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