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The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems

Authorized Users Only
2008
Authors
Đekić, Ljiljana
Ibrić, Svetlana
Primorac, Marija
Article (Published version)
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Abstract
The objective of this study was to develop artificial neural network (ANN) model suitable to predict successfully the borders of the microemulsion region in the quaternary system PEG-8 caprylic/capric glycerides (Labrasol (R)/cosurfactant/isopropyl myristate/water, in order to minimise experimental effort. In our preliminary investigations of phase behaviour, two cosurfactants were used, PEG-40 hydrogenated castor oil (Cremophor (R) RH 40) and polyglyceryl-6 isostearate (Plurol Isostearique (R)). Microemulsion existance area in pseudo-ternary phase diagrams was determined using titration method at constant: (a) oil-to-water ratio (alpha = 50%, w/w); (b) surfactant-to-cosurfactant ratio (Km) 4:6;
Keywords:
artificial neural networks / phase behaviour / microemulsions / Labrasol (R) / Cremophor (R) RH 40 / Plural Isostearique (R)
Source:
International Journal of Pharmaceutics, 2008, 361, 1-2, 41-46
Publisher:
  • Elsevier Science BV, Amsterdam
Funding / projects:
  • Sinteza, kvantitativni odnosi između strukture/osobina i aktivnosti, fizičko-hemijska karakterizacija i analiza farmakološki aktivnih supstanci (RS-142071)

DOI: 10.1016/j.ijpharm.2008.05.002

ISSN: 0378-5173

PubMed: 18571348

WoS: 000258803600007

Scopus: 2-s2.0-48049087191
[ Google Scholar ]
32
22
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1112
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Đekić, Ljiljana
AU  - Ibrić, Svetlana
AU  - Primorac, Marija
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1112
AB  - The objective of this study was to develop artificial neural network (ANN) model suitable to predict successfully the borders of the microemulsion region in the quaternary system PEG-8 caprylic/capric glycerides (Labrasol (R)/cosurfactant/isopropyl myristate/water, in order to minimise experimental effort. In our preliminary investigations of phase behaviour, two cosurfactants were used, PEG-40 hydrogenated castor oil (Cremophor (R) RH 40) and polyglyceryl-6 isostearate (Plurol Isostearique (R)). Microemulsion existance area in pseudo-ternary phase diagrams was determined using titration method at constant: (a) oil-to-water ratio (alpha = 50%, w/w); (b) surfactant-to-cosurfactant ratio (Km) 4:6;
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems
VL  - 361
IS  - 1-2
SP  - 41
EP  - 46
DO  - 10.1016/j.ijpharm.2008.05.002
ER  - 
@article{
author = "Đekić, Ljiljana and Ibrić, Svetlana and Primorac, Marija",
year = "2008",
abstract = "The objective of this study was to develop artificial neural network (ANN) model suitable to predict successfully the borders of the microemulsion region in the quaternary system PEG-8 caprylic/capric glycerides (Labrasol (R)/cosurfactant/isopropyl myristate/water, in order to minimise experimental effort. In our preliminary investigations of phase behaviour, two cosurfactants were used, PEG-40 hydrogenated castor oil (Cremophor (R) RH 40) and polyglyceryl-6 isostearate (Plurol Isostearique (R)). Microemulsion existance area in pseudo-ternary phase diagrams was determined using titration method at constant: (a) oil-to-water ratio (alpha = 50%, w/w); (b) surfactant-to-cosurfactant ratio (Km) 4:6;",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems",
volume = "361",
number = "1-2",
pages = "41-46",
doi = "10.1016/j.ijpharm.2008.05.002"
}
Đekić, L., Ibrić, S.,& Primorac, M.. (2008). The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 361(1-2), 41-46.
https://doi.org/10.1016/j.ijpharm.2008.05.002
Đekić L, Ibrić S, Primorac M. The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems. in International Journal of Pharmaceutics. 2008;361(1-2):41-46.
doi:10.1016/j.ijpharm.2008.05.002 .
Đekić, Ljiljana, Ibrić, Svetlana, Primorac, Marija, "The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems" in International Journal of Pharmaceutics, 361, no. 1-2 (2008):41-46,
https://doi.org/10.1016/j.ijpharm.2008.05.002 . .

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