The objective of this study was to develop artificial neural network (ANN) model suitable to predict successfully the borders of the microemulsion region in the quaternary system PEG-8 caprylic/capric glycerides (Labrasol (R)/cosurfactant/isopropyl myristate/water, in order to minimise experimental effort. In our preliminary investigations of phase behaviour, two cosurfactants were used, PEG-40 hydrogenated castor oil (Cremophor (R) RH 40) and polyglyceryl-6 isostearate (Plurol Isostearique (R)). Microemulsion existance area in pseudo-ternary phase diagrams was determined using titration method at constant: (a) oil-to-water ratio (alpha = 50%, w/w); (b) surfactant-to-cosurfactant ratio (Km) 4:6;
TY - JOUR
AU - Đekić, Ljiljana
AU - Ibrić, Svetlana
AU - Primorac, Marija
PY - 2008
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1112
AB - The objective of this study was to develop artificial neural network (ANN) model suitable to predict successfully the borders of the microemulsion region in the quaternary system PEG-8 caprylic/capric glycerides (Labrasol (R)/cosurfactant/isopropyl myristate/water, in order to minimise experimental effort. In our preliminary investigations of phase behaviour, two cosurfactants were used, PEG-40 hydrogenated castor oil (Cremophor (R) RH 40) and polyglyceryl-6 isostearate (Plurol Isostearique (R)). Microemulsion existance area in pseudo-ternary phase diagrams was determined using titration method at constant: (a) oil-to-water ratio (alpha = 50%, w/w); (b) surfactant-to-cosurfactant ratio (Km) 4:6;
PB - Elsevier Science BV, Amsterdam
T2 - International Journal of Pharmaceutics
T1 - The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems
VL - 361
IS - 1-2
SP - 41
EP - 46
DO - 10.1016/j.ijpharm.2008.05.002
ER -
@article{
author = "Đekić, Ljiljana and Ibrić, Svetlana and Primorac, Marija",
year = "2008",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/1112",
abstract = "The objective of this study was to develop artificial neural network (ANN) model suitable to predict successfully the borders of the microemulsion region in the quaternary system PEG-8 caprylic/capric glycerides (Labrasol (R)/cosurfactant/isopropyl myristate/water, in order to minimise experimental effort. In our preliminary investigations of phase behaviour, two cosurfactants were used, PEG-40 hydrogenated castor oil (Cremophor (R) RH 40) and polyglyceryl-6 isostearate (Plurol Isostearique (R)). Microemulsion existance area in pseudo-ternary phase diagrams was determined using titration method at constant: (a) oil-to-water ratio (alpha = 50%, w/w); (b) surfactant-to-cosurfactant ratio (Km) 4:6;",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems",
volume = "361",
number = "1-2",
pages = "41-46",
doi = "10.1016/j.ijpharm.2008.05.002"
}
Đekić, L., Ibrić, S.,& Primorac, M. (2008). The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems.
International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 361(1-2), 41-46.
https://doi.org/10.1016/j.ijpharm.2008.05.002
Đekić L, Ibrić S, Primorac M. The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems. International Journal of Pharmaceutics. 2008;361(1-2):41-46
Đekić Ljiljana, Ibrić Svetlana, Primorac Marija, "The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems" International Journal of Pharmaceutics, 361, no. 1-2 (2008):41-46,
https://doi.org/10.1016/j.ijpharm.2008.05.002 .
