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The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems
dc.creator | Đekić, Ljiljana | |
dc.creator | Ibrić, Svetlana | |
dc.creator | Primorac, Marija | |
dc.date.accessioned | 2019-09-02T11:14:29Z | |
dc.date.available | 2019-09-02T11:14:29Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0378-5173 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1112 | |
dc.description.abstract | The objective of this study was to develop artificial neural network (ANN) model suitable to predict successfully the borders of the microemulsion region in the quaternary system PEG-8 caprylic/capric glycerides (Labrasol (R)/cosurfactant/isopropyl myristate/water, in order to minimise experimental effort. In our preliminary investigations of phase behaviour, two cosurfactants were used, PEG-40 hydrogenated castor oil (Cremophor (R) RH 40) and polyglyceryl-6 isostearate (Plurol Isostearique (R)). Microemulsion existance area in pseudo-ternary phase diagrams was determined using titration method at constant: (a) oil-to-water ratio (alpha = 50%, w/w); (b) surfactant-to-cosurfactant ratio (Km) 4:6; | en |
dc.publisher | Elsevier Science BV, Amsterdam | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142071/RS// | |
dc.rights | restrictedAccess | |
dc.source | International Journal of Pharmaceutics | |
dc.subject | artificial neural networks | en |
dc.subject | phase behaviour | en |
dc.subject | microemulsions | en |
dc.subject | Labrasol (R) | en |
dc.subject | Cremophor (R) RH 40 | en |
dc.subject | Plural Isostearique (R) | en |
dc.title | The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Приморац, Марија; Ђекић, Љиљана; Ибрић, Светлана; | |
dc.citation.volume | 361 | |
dc.citation.issue | 1-2 | |
dc.citation.spage | 41 | |
dc.citation.epage | 46 | |
dc.citation.other | 361(1-2): 41-46 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000258803600007 | |
dc.identifier.doi | 10.1016/j.ijpharm.2008.05.002 | |
dc.identifier.pmid | 18571348 | |
dc.identifier.scopus | 2-s2.0-48049087191 | |
dc.type.version | publishedVersion |