Premature centromere division of the X chromosome in neurons in Alzheimer's disease

2008
Аутори
Potparević, Biljana
Živković, Lada

Đelić, Ninoslav
Plećaš-Solarović, Bosiljka
Smith, Mark A.
Bajić, Vladan

Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
Premature centromere division (PCD) represents a loss of control over the sequential separation and segregation of chromosome centromeres. Although first described in aging women, PCD on the X chromosome (PCD,X) is markedly elevated in peripheral blood lymphocytes of individuals suffering from Alzheimer disease (AD). The present study evaluated PCD,X, using a fluorescent in situ hybridization method, in interphase nuclei of frontal cerebral cortex neurons from sporadic AD patients and age-matched controls. The average frequency of PCD,X in AD patients (8.60 +/- 1.20%) was almost three times higher (p lt 0.01) than in the control group (2.96 +/- 1.20). However, consistent with previous studies, no mitotic cells were found in neurons in either AD or control brain, suggesting an intrinsic inability of post-mitotic neurons to divide. In view of the fact that it has been well-documented that neurons in AD can re-enter into the cell division cycle, the findings presented here of increased ...PCD advance the hypothesis that deregulation of the cell cycle may contribute to neuronal degeneration and subsequent cognitive deficits in AD.
Кључне речи:
Alzheimer's disease / cell cycle / fluorescent in situ hybridization / frontal cerebral cortex / premature centromere divisionИзвор:
Journal of Neurochemistry, 2008, 106, 5, 2218-2223Издавач:
- Wiley-Blackwell, Malden
Финансирање / пројекти:
- NIA NIH HHS - R21 AG031364-01
DOI: 10.1111/j.1471-4159.2008.05555.x
ISSN: 0022-3042
PubMed: 18624923
WoS: 000258360000020
Scopus: 2-s2.0-49549098397
Институција/група
PharmacyTY - JOUR AU - Potparević, Biljana AU - Živković, Lada AU - Đelić, Ninoslav AU - Plećaš-Solarović, Bosiljka AU - Smith, Mark A. AU - Bajić, Vladan PY - 2008 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1114 AB - Premature centromere division (PCD) represents a loss of control over the sequential separation and segregation of chromosome centromeres. Although first described in aging women, PCD on the X chromosome (PCD,X) is markedly elevated in peripheral blood lymphocytes of individuals suffering from Alzheimer disease (AD). The present study evaluated PCD,X, using a fluorescent in situ hybridization method, in interphase nuclei of frontal cerebral cortex neurons from sporadic AD patients and age-matched controls. The average frequency of PCD,X in AD patients (8.60 +/- 1.20%) was almost three times higher (p lt 0.01) than in the control group (2.96 +/- 1.20). However, consistent with previous studies, no mitotic cells were found in neurons in either AD or control brain, suggesting an intrinsic inability of post-mitotic neurons to divide. In view of the fact that it has been well-documented that neurons in AD can re-enter into the cell division cycle, the findings presented here of increased PCD advance the hypothesis that deregulation of the cell cycle may contribute to neuronal degeneration and subsequent cognitive deficits in AD. PB - Wiley-Blackwell, Malden T2 - Journal of Neurochemistry T1 - Premature centromere division of the X chromosome in neurons in Alzheimer's disease VL - 106 IS - 5 SP - 2218 EP - 2223 DO - 10.1111/j.1471-4159.2008.05555.x ER -
@article{ author = "Potparević, Biljana and Živković, Lada and Đelić, Ninoslav and Plećaš-Solarović, Bosiljka and Smith, Mark A. and Bajić, Vladan", year = "2008", abstract = "Premature centromere division (PCD) represents a loss of control over the sequential separation and segregation of chromosome centromeres. Although first described in aging women, PCD on the X chromosome (PCD,X) is markedly elevated in peripheral blood lymphocytes of individuals suffering from Alzheimer disease (AD). The present study evaluated PCD,X, using a fluorescent in situ hybridization method, in interphase nuclei of frontal cerebral cortex neurons from sporadic AD patients and age-matched controls. The average frequency of PCD,X in AD patients (8.60 +/- 1.20%) was almost three times higher (p lt 0.01) than in the control group (2.96 +/- 1.20). However, consistent with previous studies, no mitotic cells were found in neurons in either AD or control brain, suggesting an intrinsic inability of post-mitotic neurons to divide. In view of the fact that it has been well-documented that neurons in AD can re-enter into the cell division cycle, the findings presented here of increased PCD advance the hypothesis that deregulation of the cell cycle may contribute to neuronal degeneration and subsequent cognitive deficits in AD.", publisher = "Wiley-Blackwell, Malden", journal = "Journal of Neurochemistry", title = "Premature centromere division of the X chromosome in neurons in Alzheimer's disease", volume = "106", number = "5", pages = "2218-2223", doi = "10.1111/j.1471-4159.2008.05555.x" }
Potparević, B., Živković, L., Đelić, N., Plećaš-Solarović, B., Smith, M. A.,& Bajić, V.. (2008). Premature centromere division of the X chromosome in neurons in Alzheimer's disease. in Journal of Neurochemistry Wiley-Blackwell, Malden., 106(5), 2218-2223. https://doi.org/10.1111/j.1471-4159.2008.05555.x
Potparević B, Živković L, Đelić N, Plećaš-Solarović B, Smith MA, Bajić V. Premature centromere division of the X chromosome in neurons in Alzheimer's disease. in Journal of Neurochemistry. 2008;106(5):2218-2223. doi:10.1111/j.1471-4159.2008.05555.x .
Potparević, Biljana, Živković, Lada, Đelić, Ninoslav, Plećaš-Solarović, Bosiljka, Smith, Mark A., Bajić, Vladan, "Premature centromere division of the X chromosome in neurons in Alzheimer's disease" in Journal of Neurochemistry, 106, no. 5 (2008):2218-2223, https://doi.org/10.1111/j.1471-4159.2008.05555.x . .