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dc.creatorPotparević, Biljana
dc.creatorŽivković, Lada
dc.creatorĐelić, Ninoslav
dc.creatorPlećaš-Solarović, Bosiljka
dc.creatorSmith, Mark A.
dc.creatorBajić, Vladan
dc.date.accessioned2019-09-02T11:14:34Z
dc.date.available2019-09-02T11:14:34Z
dc.date.issued2008
dc.identifier.issn0022-3042
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1114
dc.description.abstractPremature centromere division (PCD) represents a loss of control over the sequential separation and segregation of chromosome centromeres. Although first described in aging women, PCD on the X chromosome (PCD,X) is markedly elevated in peripheral blood lymphocytes of individuals suffering from Alzheimer disease (AD). The present study evaluated PCD,X, using a fluorescent in situ hybridization method, in interphase nuclei of frontal cerebral cortex neurons from sporadic AD patients and age-matched controls. The average frequency of PCD,X in AD patients (8.60 +/- 1.20%) was almost three times higher (p lt 0.01) than in the control group (2.96 +/- 1.20). However, consistent with previous studies, no mitotic cells were found in neurons in either AD or control brain, suggesting an intrinsic inability of post-mitotic neurons to divide. In view of the fact that it has been well-documented that neurons in AD can re-enter into the cell division cycle, the findings presented here of increased PCD advance the hypothesis that deregulation of the cell cycle may contribute to neuronal degeneration and subsequent cognitive deficits in AD.en
dc.publisherWiley-Blackwell, Malden
dc.relationNIA NIH HHS - R21 AG031364-01
dc.rightsopenAccess
dc.sourceJournal of Neurochemistry
dc.subjectAlzheimer's diseaseen
dc.subjectcell cycleen
dc.subjectfluorescent in situ hybridizationen
dc.subjectfrontal cerebral cortexen
dc.subjectpremature centromere divisionen
dc.titlePremature centromere division of the X chromosome in neurons in Alzheimer's diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПлећаш-Соларовић, Босиљка; Живковић, Лада; Потпаревић, Биљана; Ђелић, Нинослав; Бајић, Владан; Смитх, Марк A.;
dc.citation.volume106
dc.citation.issue5
dc.citation.spage2218
dc.citation.epage2223
dc.citation.other106(5): 2218-2223
dc.citation.rankM21
dc.identifier.wos000258360000020
dc.identifier.doi10.1111/j.1471-4159.2008.05555.x
dc.identifier.pmid18624923
dc.identifier.scopus2-s2.0-49549098397
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/83/1112.pdf
dc.type.versionpublishedVersion


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