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Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects

Samo za registrovane korisnike
2008
Autori
Topić, Aleksandra
Spasojević-Kalimanovska, Vesna
Zeljković, Aleksandra
Vekić, Jelena
Jelić-Ivanović, Zorana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentu
Apstrakt
Objectives: We determined the frequencies of apolipoprotein E (apo E) alleles and examined the effect of apo E polymorphism on lipoprotein particle sizes in Serbian healthy, middle-aged individuals. Design and methods: We performed apo E phenotype by immunobloting method in 183 men and 143 women (mean years: 56.3 +/- 10.60 and 54.9 +/- 10.31, respectively). Plasma lipid and apolipoprotein levels were measured by routine laboratory methods. LDL and HDL particle sizes were determined by nondenaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: The apo E allele frequencies were epsilon 2-4.9%, epsilon 3-86.5%, and epsilon 4-8.6%. Men with epsilon 4 allele had lower HDL-C and Apo AI concentrations than epsilon 3 men. The epsilon 2 allele men had the smallest LDL particles, highest percent of subjects with LDL phenotype B and highest TG/HDL-C ratio. Women with epsilon 2 allele had lowest concentration of apo B. The epsilon 4 allele women had smallest HDL particles and high...est percent of the subjects with small-sized HDL phenotype. Conclusions: This study showed gender-related effect of apo E polymorphism on lipoprotein particle size. In men, possession of the 62 allele is associated with small LDL particles, whereas in women, epsilon 4 allele is associated with small HDL particles. Differences in gender-related influence of apo E polymorphism on LDL and HDL particle sizes could be clinically useful in strategy for reduction of coronary disease risk in middle-aged men and women.

Ključne reči:
apo E / polymorphism / LDL particle size / HDL particle size
Izvor:
Clinical Biochemistry, 2008, 41, 6, 361-367
Izdavač:
  • Pergamon-Elsevier Science Ltd, Oxford
Finansiranje / projekti:
  • Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-145036)

DOI: 10.1016/j.clinbiochem.2007.11.013

ISSN: 0009-9120

PubMed: 18086568

WoS: 000254648400003

Scopus: 2-s2.0-40849135889
[ Google Scholar ]
9
9
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1120
Kolekcije
  • Radovi istraživača / Researchers’ publications
Institucija/grupa
Pharmacy
TY  - JOUR
AU  - Topić, Aleksandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Jelić-Ivanović, Zorana
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1120
AB  - Objectives: We determined the frequencies of apolipoprotein E (apo E) alleles and examined the effect of apo E polymorphism on lipoprotein particle sizes in Serbian healthy, middle-aged individuals. Design and methods: We performed apo E phenotype by immunobloting method in 183 men and 143 women (mean years: 56.3 +/- 10.60 and 54.9 +/- 10.31, respectively). Plasma lipid and apolipoprotein levels were measured by routine laboratory methods. LDL and HDL particle sizes were determined by nondenaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: The apo E allele frequencies were epsilon 2-4.9%, epsilon 3-86.5%, and epsilon 4-8.6%. Men with epsilon 4 allele had lower HDL-C and Apo AI concentrations than epsilon 3 men. The epsilon 2 allele men had the smallest LDL particles, highest percent of subjects with LDL phenotype B and highest TG/HDL-C ratio. Women with epsilon 2 allele had lowest concentration of apo B. The epsilon 4 allele women had smallest HDL particles and highest percent of the subjects with small-sized HDL phenotype. Conclusions: This study showed gender-related effect of apo E polymorphism on lipoprotein particle size. In men, possession of the 62 allele is associated with small LDL particles, whereas in women, epsilon 4 allele is associated with small HDL particles. Differences in gender-related influence of apo E polymorphism on LDL and HDL particle sizes could be clinically useful in strategy for reduction of coronary disease risk in middle-aged men and women.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects
VL  - 41
IS  - 6
SP  - 361
EP  - 367
DO  - 10.1016/j.clinbiochem.2007.11.013
UR  - conv_1978
ER  - 
@article{
author = "Topić, Aleksandra and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Vekić, Jelena and Jelić-Ivanović, Zorana",
year = "2008",
abstract = "Objectives: We determined the frequencies of apolipoprotein E (apo E) alleles and examined the effect of apo E polymorphism on lipoprotein particle sizes in Serbian healthy, middle-aged individuals. Design and methods: We performed apo E phenotype by immunobloting method in 183 men and 143 women (mean years: 56.3 +/- 10.60 and 54.9 +/- 10.31, respectively). Plasma lipid and apolipoprotein levels were measured by routine laboratory methods. LDL and HDL particle sizes were determined by nondenaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: The apo E allele frequencies were epsilon 2-4.9%, epsilon 3-86.5%, and epsilon 4-8.6%. Men with epsilon 4 allele had lower HDL-C and Apo AI concentrations than epsilon 3 men. The epsilon 2 allele men had the smallest LDL particles, highest percent of subjects with LDL phenotype B and highest TG/HDL-C ratio. Women with epsilon 2 allele had lowest concentration of apo B. The epsilon 4 allele women had smallest HDL particles and highest percent of the subjects with small-sized HDL phenotype. Conclusions: This study showed gender-related effect of apo E polymorphism on lipoprotein particle size. In men, possession of the 62 allele is associated with small LDL particles, whereas in women, epsilon 4 allele is associated with small HDL particles. Differences in gender-related influence of apo E polymorphism on LDL and HDL particle sizes could be clinically useful in strategy for reduction of coronary disease risk in middle-aged men and women.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects",
volume = "41",
number = "6",
pages = "361-367",
doi = "10.1016/j.clinbiochem.2007.11.013",
url = "conv_1978"
}
Topić, A., Spasojević-Kalimanovska, V., Zeljković, A., Vekić, J.,& Jelić-Ivanović, Z.. (2008). Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 41(6), 361-367.
https://doi.org/10.1016/j.clinbiochem.2007.11.013
conv_1978
Topić A, Spasojević-Kalimanovska V, Zeljković A, Vekić J, Jelić-Ivanović Z. Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects. in Clinical Biochemistry. 2008;41(6):361-367.
doi:10.1016/j.clinbiochem.2007.11.013
conv_1978 .
Topić, Aleksandra, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Vekić, Jelena, Jelić-Ivanović, Zorana, "Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects" in Clinical Biochemistry, 41, no. 6 (2008):361-367,
https://doi.org/10.1016/j.clinbiochem.2007.11.013 .,
conv_1978 .

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