Show simple item record

dc.creatorTopić, Aleksandra
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorZeljković, Aleksandra
dc.creatorVekić, Jelena
dc.creatorJelić-Ivanović, Zorana
dc.date.accessioned2019-09-02T11:14:43Z
dc.date.available2019-09-02T11:14:43Z
dc.date.issued2008
dc.identifier.issn0009-9120
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1120
dc.description.abstractObjectives: We determined the frequencies of apolipoprotein E (apo E) alleles and examined the effect of apo E polymorphism on lipoprotein particle sizes in Serbian healthy, middle-aged individuals. Design and methods: We performed apo E phenotype by immunobloting method in 183 men and 143 women (mean years: 56.3 +/- 10.60 and 54.9 +/- 10.31, respectively). Plasma lipid and apolipoprotein levels were measured by routine laboratory methods. LDL and HDL particle sizes were determined by nondenaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: The apo E allele frequencies were epsilon 2-4.9%, epsilon 3-86.5%, and epsilon 4-8.6%. Men with epsilon 4 allele had lower HDL-C and Apo AI concentrations than epsilon 3 men. The epsilon 2 allele men had the smallest LDL particles, highest percent of subjects with LDL phenotype B and highest TG/HDL-C ratio. Women with epsilon 2 allele had lowest concentration of apo B. The epsilon 4 allele women had smallest HDL particles and highest percent of the subjects with small-sized HDL phenotype. Conclusions: This study showed gender-related effect of apo E polymorphism on lipoprotein particle size. In men, possession of the 62 allele is associated with small LDL particles, whereas in women, epsilon 4 allele is associated with small HDL particles. Differences in gender-related influence of apo E polymorphism on LDL and HDL particle sizes could be clinically useful in strategy for reduction of coronary disease risk in middle-aged men and women.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Biochemistry
dc.subjectapo Een
dc.subjectpolymorphismen
dc.subjectLDL particle sizeen
dc.subjectHDL particle sizeen
dc.titleGender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjectsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТопић, Aлександра; Зељковић, Aлександра; Векић, Јелена; Јелић-Ивановић, Зорана; Спасојевић-Калимановска, Весна;
dc.citation.volume41
dc.citation.issue6
dc.citation.spage361
dc.citation.epage367
dc.citation.other41(6): 361-367
dc.citation.rankM22
dc.identifier.wos000254648400003
dc.identifier.doi10.1016/j.clinbiochem.2007.11.013
dc.identifier.pmid18086568
dc.identifier.scopus2-s2.0-40849135889
dc.identifier.rcubconv_1978
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record