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Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects
dc.creator | Topić, Aleksandra | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.creator | Zeljković, Aleksandra | |
dc.creator | Vekić, Jelena | |
dc.creator | Jelić-Ivanović, Zorana | |
dc.date.accessioned | 2019-09-02T11:14:43Z | |
dc.date.available | 2019-09-02T11:14:43Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0009-9120 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1120 | |
dc.description.abstract | Objectives: We determined the frequencies of apolipoprotein E (apo E) alleles and examined the effect of apo E polymorphism on lipoprotein particle sizes in Serbian healthy, middle-aged individuals. Design and methods: We performed apo E phenotype by immunobloting method in 183 men and 143 women (mean years: 56.3 +/- 10.60 and 54.9 +/- 10.31, respectively). Plasma lipid and apolipoprotein levels were measured by routine laboratory methods. LDL and HDL particle sizes were determined by nondenaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: The apo E allele frequencies were epsilon 2-4.9%, epsilon 3-86.5%, and epsilon 4-8.6%. Men with epsilon 4 allele had lower HDL-C and Apo AI concentrations than epsilon 3 men. The epsilon 2 allele men had the smallest LDL particles, highest percent of subjects with LDL phenotype B and highest TG/HDL-C ratio. Women with epsilon 2 allele had lowest concentration of apo B. The epsilon 4 allele women had smallest HDL particles and highest percent of the subjects with small-sized HDL phenotype. Conclusions: This study showed gender-related effect of apo E polymorphism on lipoprotein particle size. In men, possession of the 62 allele is associated with small LDL particles, whereas in women, epsilon 4 allele is associated with small HDL particles. Differences in gender-related influence of apo E polymorphism on LDL and HDL particle sizes could be clinically useful in strategy for reduction of coronary disease risk in middle-aged men and women. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical Biochemistry | |
dc.subject | apo E | en |
dc.subject | polymorphism | en |
dc.subject | LDL particle size | en |
dc.subject | HDL particle size | en |
dc.title | Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Топић, Aлександра; Зељковић, Aлександра; Векић, Јелена; Јелић-Ивановић, Зорана; Спасојевић-Калимановска, Весна; | |
dc.citation.volume | 41 | |
dc.citation.issue | 6 | |
dc.citation.spage | 361 | |
dc.citation.epage | 367 | |
dc.citation.other | 41(6): 361-367 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000254648400003 | |
dc.identifier.doi | 10.1016/j.clinbiochem.2007.11.013 | |
dc.identifier.pmid | 18086568 | |
dc.identifier.scopus | 2-s2.0-40849135889 | |
dc.type.version | publishedVersion |