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Brain stem and thalamus antioxidative defensein experimental sepsis

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2008
Authors
Ninković, Milica
Maličević, Živorad
Stojanović, Dragica
Vasiljević, Ivana
Jovanović, Marina
Đukić, Mirjana
Article (Published version)
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Abstract
Although brain complications in sepsis are not rare, early pathophysiologic events had not been made clear yet. We have considered antioxidative components-glutathione peroxidase (GSHPx) activity and reduced glutathione (GSH) concentration in two brain integrative centers, Le the brain stem (BS) and thalamus. Sepsis was induced in adult male Wistar rats (200-250 g) by cecal ligation and perforation (CLP) with inoculation of Escherichia coli suspension (ATCC 25922) (n=40). The control group was sham operated (n=40). For each time point (0, 12, 24 and 72 hours) after treatment, ten animals within each group were decapitated. In BS, GSHPx activity increased at 12 and 24 hours after CLP, while in the thalamus, GSHPx activity increased at 72 hours, compared to controls. In BS, GSH concentration decreased at the 12(th) and 24(th) hour, and in the thalamus it decreased at the 72(nd) hour. Changed oxidative status in BS, recorded as soon as the 12(th) hour reflects a prompt reaction of the cen...tral nervous system. This could be of great consequence for disturbed vasomotor response during sepsis.

Keywords:
brain stem / glutathione / glutathione peroxydase / rat / sepsis / thalamus
Source:
Acta veterinaria, 2008, 58, 2-3, 129-137
Publisher:
  • Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Projects:
  • Military Medical Academy, Republic of Serbia

DOI: 10.2298/AVB0803129N

ISSN: 0567-8315

WoS: 000258838000003

Scopus: 2-s2.0-48949103052
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1121
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Institution
Pharmacy

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