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dc.creatorNinković, Milica
dc.creatorMaličević, Živorad
dc.creatorStojanović, Dragica
dc.creatorVasiljević, Ivana
dc.creatorJovanović, Marina
dc.creatorĐukić, Mirjana
dc.date.accessioned2019-09-02T11:14:44Z
dc.date.available2019-09-02T11:14:44Z
dc.date.issued2008
dc.identifier.issn0567-8315
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1121
dc.description.abstractAlthough brain complications in sepsis are not rare, early pathophysiologic events had not been made clear yet. We have considered antioxidative components-glutathione peroxidase (GSHPx) activity and reduced glutathione (GSH) concentration in two brain integrative centers, Le the brain stem (BS) and thalamus. Sepsis was induced in adult male Wistar rats (200-250 g) by cecal ligation and perforation (CLP) with inoculation of Escherichia coli suspension (ATCC 25922) (n=40). The control group was sham operated (n=40). For each time point (0, 12, 24 and 72 hours) after treatment, ten animals within each group were decapitated. In BS, GSHPx activity increased at 12 and 24 hours after CLP, while in the thalamus, GSHPx activity increased at 72 hours, compared to controls. In BS, GSH concentration decreased at the 12(th) and 24(th) hour, and in the thalamus it decreased at the 72(nd) hour. Changed oxidative status in BS, recorded as soon as the 12(th) hour reflects a prompt reaction of the central nervous system. This could be of great consequence for disturbed vasomotor response during sepsis.en
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.relationMilitary Medical Academy, Republic of Serbia
dc.rightsrestrictedAccess
dc.sourceActa veterinaria
dc.subjectbrain stemen
dc.subjectglutathioneen
dc.subjectglutathione peroxydaseen
dc.subjectraten
dc.subjectsepsisen
dc.subjectthalamusen
dc.titleBrain stem and thalamus antioxidative defensein experimental sepsisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМаличевић, Живорад; Стојановић, Драгица; Ђукић, Мирјана; Нинковић, Милица; Васиљевић, Ивана; Јовановић, Марина;
dc.citation.volume58
dc.citation.issue2-3
dc.citation.spage129
dc.citation.epage137
dc.citation.other58(2-3): 129-137
dc.citation.rankM23
dc.identifier.wos000258838000003
dc.identifier.doi10.2298/AVB0803129N
dc.identifier.scopus2-s2.0-48949103052
dc.type.versionpublishedVersion


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