QSAR study of imidazoline antihypertensive drugs
Само за регистроване кориснике
2008
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The hypotensive effect of imidazoline ligands was attributed to both alpha(2)-adrenergic receptors and nonadrenergic imidazoline-1 receptors (I-1-R). Selective I-1-R ligands, devoid of the typical side effects of other centrally acting antihypertensive drugs, could be widely used in antihypertensive therapy. Thus, there is significant interest in developing new imidazoline analogs with higher selectivity and affinity for I-1-receptors. The quantitative structure-activity relationship (QSAR) study of 12 ligands was carried out using multilinear regression method on I-1-R and alpha(2)-adrenergic receptors binding affinities on human platelets. The compounds have been studied using Becke3LYP/3-21G (d, p) and Becke3LYP/6-31G(d, p) DFT methods. Among 42 descriptors that were considered in generating the QSAR model, three descriptors such as partial atomic charges of nitrogen in the heterocyclic moiety, distribution coefficient, and molar refractivity of the ligands resulted in a statistical...ly significant model with R-2 = 0.935 and cross-validation parameter q(pre)(2) = 0.803. The validation of the QSAR models was done by cross-validation and external test set prediction. The developed multiple linear regression models for the I-1-R ligands were aimed to link the structures to their reported I-1-R binding affinity log(1/K-i). The theoretical approach indicates that an increase in distribution coefficient and molar refractivity value, together with a decrease in average N-charge in the heterocyclic moiety of the ligands, causes better binding affinity for active site of the I-1 receptors. The developed QSAR model is intended to predict I-1-R binding affinity of related compounds and to de. ne possible physicochemical, electronical, and structural requirements for selective I-1-receptor ligands.
Кључне речи:
I-1-receptor / I-1-R ligands / centrally acting antihypertensives / structure activity relationship / pharmacophoreИзвор:
Bioorganic & Medicinal Chemistry, 2008, 16, 15, 7134-7140Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
DOI: 10.1016/j.bmc.2008.06.051
ISSN: 0968-0896
PubMed: 18621536
WoS: 000258749500006
Scopus: 2-s2.0-84962448550
Институција/група
PharmacyTY - JOUR AU - Nikolić, Katarina AU - Filipić, Slavica AU - Agbaba, Danica PY - 2008 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1124 AB - The hypotensive effect of imidazoline ligands was attributed to both alpha(2)-adrenergic receptors and nonadrenergic imidazoline-1 receptors (I-1-R). Selective I-1-R ligands, devoid of the typical side effects of other centrally acting antihypertensive drugs, could be widely used in antihypertensive therapy. Thus, there is significant interest in developing new imidazoline analogs with higher selectivity and affinity for I-1-receptors. The quantitative structure-activity relationship (QSAR) study of 12 ligands was carried out using multilinear regression method on I-1-R and alpha(2)-adrenergic receptors binding affinities on human platelets. The compounds have been studied using Becke3LYP/3-21G (d, p) and Becke3LYP/6-31G(d, p) DFT methods. Among 42 descriptors that were considered in generating the QSAR model, three descriptors such as partial atomic charges of nitrogen in the heterocyclic moiety, distribution coefficient, and molar refractivity of the ligands resulted in a statistically significant model with R-2 = 0.935 and cross-validation parameter q(pre)(2) = 0.803. The validation of the QSAR models was done by cross-validation and external test set prediction. The developed multiple linear regression models for the I-1-R ligands were aimed to link the structures to their reported I-1-R binding affinity log(1/K-i). The theoretical approach indicates that an increase in distribution coefficient and molar refractivity value, together with a decrease in average N-charge in the heterocyclic moiety of the ligands, causes better binding affinity for active site of the I-1 receptors. The developed QSAR model is intended to predict I-1-R binding affinity of related compounds and to de. ne possible physicochemical, electronical, and structural requirements for selective I-1-receptor ligands. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Bioorganic & Medicinal Chemistry T1 - QSAR study of imidazoline antihypertensive drugs VL - 16 IS - 15 SP - 7134 EP - 7140 DO - 10.1016/j.bmc.2008.06.051 ER -
@article{ author = "Nikolić, Katarina and Filipić, Slavica and Agbaba, Danica", year = "2008", abstract = "The hypotensive effect of imidazoline ligands was attributed to both alpha(2)-adrenergic receptors and nonadrenergic imidazoline-1 receptors (I-1-R). Selective I-1-R ligands, devoid of the typical side effects of other centrally acting antihypertensive drugs, could be widely used in antihypertensive therapy. Thus, there is significant interest in developing new imidazoline analogs with higher selectivity and affinity for I-1-receptors. The quantitative structure-activity relationship (QSAR) study of 12 ligands was carried out using multilinear regression method on I-1-R and alpha(2)-adrenergic receptors binding affinities on human platelets. The compounds have been studied using Becke3LYP/3-21G (d, p) and Becke3LYP/6-31G(d, p) DFT methods. Among 42 descriptors that were considered in generating the QSAR model, three descriptors such as partial atomic charges of nitrogen in the heterocyclic moiety, distribution coefficient, and molar refractivity of the ligands resulted in a statistically significant model with R-2 = 0.935 and cross-validation parameter q(pre)(2) = 0.803. The validation of the QSAR models was done by cross-validation and external test set prediction. The developed multiple linear regression models for the I-1-R ligands were aimed to link the structures to their reported I-1-R binding affinity log(1/K-i). The theoretical approach indicates that an increase in distribution coefficient and molar refractivity value, together with a decrease in average N-charge in the heterocyclic moiety of the ligands, causes better binding affinity for active site of the I-1 receptors. The developed QSAR model is intended to predict I-1-R binding affinity of related compounds and to de. ne possible physicochemical, electronical, and structural requirements for selective I-1-receptor ligands.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Bioorganic & Medicinal Chemistry", title = "QSAR study of imidazoline antihypertensive drugs", volume = "16", number = "15", pages = "7134-7140", doi = "10.1016/j.bmc.2008.06.051" }
Nikolić, K., Filipić, S.,& Agbaba, D.. (2008). QSAR study of imidazoline antihypertensive drugs. in Bioorganic & Medicinal Chemistry Pergamon-Elsevier Science Ltd, Oxford., 16(15), 7134-7140. https://doi.org/10.1016/j.bmc.2008.06.051
Nikolić K, Filipić S, Agbaba D. QSAR study of imidazoline antihypertensive drugs. in Bioorganic & Medicinal Chemistry. 2008;16(15):7134-7140. doi:10.1016/j.bmc.2008.06.051 .
Nikolić, Katarina, Filipić, Slavica, Agbaba, Danica, "QSAR study of imidazoline antihypertensive drugs" in Bioorganic & Medicinal Chemistry, 16, no. 15 (2008):7134-7140, https://doi.org/10.1016/j.bmc.2008.06.051 . .