The new group of antimicrobial drugs: Chemistry of glycylcyclines
Nova grupa antimikrobnih lekova - hemija glicilciklina
Апстракт
Human and veterinary medicines, since the late forties of the 20th century, have increasingly used tetracyclines as broad spectrum antibiotics. The wide and long-lasting usage of all antibiotics, including tetracyclines, accordingly causes a widespread microbial resistance. At the beginning of the nineties, the synthesis of a new antibiotics' group, including tetracyclic structure showing more active antibacterial potency and widespread spectrum activity on the existing resistant microorganisms' forms, have been reported and called glycylcyclines. The group development, its chemistry and the first launched tigecycline properties will be shown in this paper.
Humana i veterinarska medicina, s kraja četrdesetih godina prošlog veka, je koristila tetracikline kao antibiotike širokog spektra dejstva. Obimna i duga upotreba svih antibiotika, uključujući i tetracikline, dovela je do pojave porasta rezistencije. Početkom devedesetih godina, objavljena je sinteza nove grupe antibiotika tetraciklične strukture, te je grupa koja je pokazala najjaču antimikrobnu aktivnost, najširi spektar dejstva na postojeće rezistentne forme mikroorganizama, nazvana glicilciklini. Razvoj ove grupe antibiotika, kao i hemija i osobine prvog registrovanog tigeciklina, prikazane su u ovom radu.
Извор:
Arhiv za farmaciju, 2008, 58, 1, 1-8Издавач:
- Savez farmaceutskih udruženja Srbije, Beograd
Институција/група
PharmacyTY - JOUR AU - Agbaba, Danica AU - Marković, Bojan PY - 2008 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1130 AB - Human and veterinary medicines, since the late forties of the 20th century, have increasingly used tetracyclines as broad spectrum antibiotics. The wide and long-lasting usage of all antibiotics, including tetracyclines, accordingly causes a widespread microbial resistance. At the beginning of the nineties, the synthesis of a new antibiotics' group, including tetracyclic structure showing more active antibacterial potency and widespread spectrum activity on the existing resistant microorganisms' forms, have been reported and called glycylcyclines. The group development, its chemistry and the first launched tigecycline properties will be shown in this paper. AB - Humana i veterinarska medicina, s kraja četrdesetih godina prošlog veka, je koristila tetracikline kao antibiotike širokog spektra dejstva. Obimna i duga upotreba svih antibiotika, uključujući i tetracikline, dovela je do pojave porasta rezistencije. Početkom devedesetih godina, objavljena je sinteza nove grupe antibiotika tetraciklične strukture, te je grupa koja je pokazala najjaču antimikrobnu aktivnost, najširi spektar dejstva na postojeće rezistentne forme mikroorganizama, nazvana glicilciklini. Razvoj ove grupe antibiotika, kao i hemija i osobine prvog registrovanog tigeciklina, prikazane su u ovom radu. PB - Savez farmaceutskih udruženja Srbije, Beograd T2 - Arhiv za farmaciju T1 - The new group of antimicrobial drugs: Chemistry of glycylcyclines T1 - Nova grupa antimikrobnih lekova - hemija glicilciklina VL - 58 IS - 1 SP - 1 EP - 8 UR - https://hdl.handle.net/21.15107/rcub_farfar_1130 ER -
@article{ author = "Agbaba, Danica and Marković, Bojan", year = "2008", abstract = "Human and veterinary medicines, since the late forties of the 20th century, have increasingly used tetracyclines as broad spectrum antibiotics. The wide and long-lasting usage of all antibiotics, including tetracyclines, accordingly causes a widespread microbial resistance. At the beginning of the nineties, the synthesis of a new antibiotics' group, including tetracyclic structure showing more active antibacterial potency and widespread spectrum activity on the existing resistant microorganisms' forms, have been reported and called glycylcyclines. The group development, its chemistry and the first launched tigecycline properties will be shown in this paper., Humana i veterinarska medicina, s kraja četrdesetih godina prošlog veka, je koristila tetracikline kao antibiotike širokog spektra dejstva. Obimna i duga upotreba svih antibiotika, uključujući i tetracikline, dovela je do pojave porasta rezistencije. Početkom devedesetih godina, objavljena je sinteza nove grupe antibiotika tetraciklične strukture, te je grupa koja je pokazala najjaču antimikrobnu aktivnost, najširi spektar dejstva na postojeće rezistentne forme mikroorganizama, nazvana glicilciklini. Razvoj ove grupe antibiotika, kao i hemija i osobine prvog registrovanog tigeciklina, prikazane su u ovom radu.", publisher = "Savez farmaceutskih udruženja Srbije, Beograd", journal = "Arhiv za farmaciju", title = "The new group of antimicrobial drugs: Chemistry of glycylcyclines, Nova grupa antimikrobnih lekova - hemija glicilciklina", volume = "58", number = "1", pages = "1-8", url = "https://hdl.handle.net/21.15107/rcub_farfar_1130" }
Agbaba, D.,& Marković, B.. (2008). The new group of antimicrobial drugs: Chemistry of glycylcyclines. in Arhiv za farmaciju Savez farmaceutskih udruženja Srbije, Beograd., 58(1), 1-8. https://hdl.handle.net/21.15107/rcub_farfar_1130
Agbaba D, Marković B. The new group of antimicrobial drugs: Chemistry of glycylcyclines. in Arhiv za farmaciju. 2008;58(1):1-8. https://hdl.handle.net/21.15107/rcub_farfar_1130 .
Agbaba, Danica, Marković, Bojan, "The new group of antimicrobial drugs: Chemistry of glycylcyclines" in Arhiv za farmaciju, 58, no. 1 (2008):1-8, https://hdl.handle.net/21.15107/rcub_farfar_1130 .