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dc.creatorVekić, Jelena
dc.creatorKotur-Stevuljević, Jelena
dc.creatorZeljković, Aleksandra
dc.creatorStefanović, Aleksandra
dc.creatorBogavac-Stanojević, Nataša
dc.creatorVujović, Ana
dc.date.accessioned2019-09-02T11:15:14Z
dc.date.available2019-09-02T11:15:14Z
dc.date.issued2008
dc.identifier.issn1871-5230
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1139
dc.description.abstractOxidative stress is a result of an imbalanced equilibrium between reactive oxygen species (ROS) generation and their elimination by antioxidants. There is substantial evidence indicating that exacerbated oxidative stress is relevant for the development of atherosclerosis and its associated complications, especially cardiovascular disease (CVD). According to the oxidative modification hypothesis, oxidised low density lipoproteins (LDL) induce atherosclerosis by triggering an inflammatory cascade within the vascular wall. This process can be inhibited or delayed by the antioxidative and anti-inflammatory actions of high density lipoproteins (HDL). Clearly, paraoxonase-1 (PON1) is one of the most important contributors to the antioxidative capacity of HDL. Atherogenic dyslipidemia, oxidative stress and inflammatory conditions induce dramatic changes in HDL composition that considerably alters or attenuates HDL's anti-atherogenic effects. Such impairment of HDL's functions provides an important link between oxidative stress and inflammation in the pathogenesis of atherosclerosis. This review summarises and discusses the possible synergistic effects of dyslipidemia, oxidative stress and inflammation in promoting atherosclerosis and its complications, as well as potential benefits of therapeutic modulation of HDL's atheroprotective activity.en
dc.rightsrestrictedAccess
dc.sourceAnti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry
dc.subjectAtherosclerosisen
dc.subjectCardiovascular diseaseen
dc.subjectDiabetesen
dc.subjectHDLen
dc.subjectInflammationen
dc.subjectOxidative stressen
dc.subjectParaoxonaseen
dc.titleOxidative stress, HDL and atherosclerosisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБогавац-Станојевић, Наташа; Стефановић, Aлександра; Вујовић, Aна; Векић, Јелена; Котур-Стевуљевић, Јелена; Зељковић, Aлександра;
dc.citation.volume7
dc.citation.issue3
dc.citation.spage158
dc.citation.epage165
dc.citation.other7(3): 158-165
dc.identifier.doi10.2174/187152308785699281
dc.identifier.scopus2-s2.0-54349128390
dc.identifier.rcubconv_5088
dc.type.versionpublishedVersion


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